A two‐component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae
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Summary
Virulence‐associated changes were demonstrated in the attenuated strain with significant downregulation of a previously determined virulence locus, pSAB, psaC and psaA, and a serotype‐specific attenuation of virulence due to deletion of rr04 was identified.
- Type
- article
- Published
- 2004-03-01
- Cited by
- 101
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1927359839
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13939963
Keywords
Virulence, Biology, Streptococcus pneumoniae, Microbiology, Mutant
References
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- Large‐scale identification of serotype 4 Streptococcus pneumoniae virulence factors
- Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases
- Genetic Characterization of a Streptococcus mutans LraI Family Operon and Role in Virulence
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- Chemosensing and signal transduction in bacteria.
- Generation and characterization of a PhoP homologue mutant of Neisseria meningitidis
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- Microarray-Based Identification of a NovelStreptococcus pneumoniae Regulon Controlled by an Autoinduced Peptide
- The signal‐transduction network for Pho regulation in Bacillus subtilis
Cited by
- Central Role of Manganese in Regulation of Stress Responses, Physiology, and Metabolism in Streptococcus pneumoniae
- Deletion of a Cation Transporter Promotes Lysis in Streptococcus pneumoniae
- Intracellular Streptococcus pneumoniae develops enhanced fluoroquinolone persistence during influenza A coinfection
- Understanding the relationship betweencentral metabolism and virulence in thehuman pathogen Streptococcus pneumoniae
- Screening of streptococcus pneumoniae ABC transporters for their role in virulence and investigation of their lipoprotein components as vaccine candidates
- Stress response and pathogenicity in Streptococcus pneumoniae
- Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae
- Prise en charge des pneumonies graves à pneumocoque — Pneumonies communautaires aiguës sévères à Streptococcus pneumoniae (PAC Sp): rôle de l’hôte et des facteurs de virulence bactérienne
- Environmental interactions of Lactobacillus reuteri
- Stress responses in Streptococcus species and their effects on the host
- Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells
- A Three-Tiered Study of Differences in Murine Intrahost Immune Response to Multiple Pneumococcal Strains
- Analysis of the growth phase-associated transcriptome of Streptococcus pyogenes.
- The growth phase-dependent regulation of the pilus locus genes by two-component system TCS08 in Streptococcus pneumoniae.
- Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice.
- Characterization of Two Signal Transduction Systems Involved in Intracellular Macrophage Survival and Environmental Stress Response in Enterococcus faecalis
- Extracellular Matrix Formation Enhances the Ability of Streptococcus pneumoniae to Cause Invasive Disease
- Competence in Streptococcus pneumoniae Is a Response to an Increasing Mutational Burden
- Oxidative stress and heat-shock responses in Desulfovibrio vulgaris by genome-wide transcriptomic analysis
- A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates
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