A two‐component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae

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Summary

Virulence‐associated changes were demonstrated in the attenuated strain with significant downregulation of a previously determined virulence locus, pSAB, psaC and psaA, and a serotype‐specific attenuation of virulence due to deletion of rr04 was identified.

Type
article
Published
2004-03-01
Cited by
101
References
54
Access
Open access

Keywords

Virulence, Biology, Streptococcus pneumoniae, Microbiology, Mutant

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