Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
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Summary
The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs, which suggest their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors.
- Type
- article
- Published
- 1997-12-11
- Cited by
- 2,134
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1926303070
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4388492
Keywords
Biology, Plasmid, Genetics, Gene, Borrelia burgdorferi
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- Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.
- Consequences of replication fork movement through transcription units in vivo.
- Sequence analysis of the ribosomal RNA operon of the Lyme disease spirochete, Borrelia burgdorferi.
- Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends.
Cited by
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- The genome of Treponema pallidum: new light on the agent of syphilis.
- Regulation of the Bacillus subtilis pyrimidine biosynthetic operon by transcriptional attenuation: control of gene expression by an mRNA-binding protein.
- Tyrosine Aminotransferase Catalyzes the Final Step of Methionine Recycling in Klebsiella pneumoniae
- Pervasiveness of Gene Conservation and Persistence of Duplicates in Cellular Genomes
- Genome evolution and the evolution of exon-shuffling--a review.
- D-ribose-5-phosphate isomerase from spinach: heterologous overexpression, purification, characterization, and site-directed mutagenesis of the recombinant enzyme.
- Pathogen virulence genes--implications for vaccines and drug therapy.
- Distribution of Twelve Linear Extrachromosomal DNAs in Natural Isolates of Lyme Disease Spirochetes
- The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways
- Characterization of the dnaK Multigene Family in the Cyanobacterium Synechococcus sp. Strain PCC7942
- Sequencing, high-level expression and phylogeny of the pyrophosphate-dependent phosphofructokinase from the thermophilic spirochete Spirochaeta thermophila
- Genome Information Broker (GIB): data retrieval and comparative analysis system for completed microbial genomes and more
- Mutations within the putative active site of heterodimeric deoxyguanosine kinase block the allosteric activation of the deoxyadenosine kinase subunit.
- Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri.
- The Urokinase Receptor Can Be Induced by Borrelia burgdorferi through Receptors of the Innate Immune System
- Multiplex Real-Time PCR for Detection of Anaplasma phagocytophilum and Borrelia burgdorferi
- Conservation of adjacency as evidence of paralogous operons.
- Analysis of Promoter Elements Involved in the Transcriptional Initiation of RpoS-Dependent Borrelia burgdorferi Genes
- Relapsing Fever Spirochetes Contain Chromosomal Genes with Unique Direct Tandemly Repeated Sequences
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