Effects of cholinergic and anticholinergic drugs and a partial cholinergic agonist on the development and expression of physical dependence on morphine in rat.
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Summary
The reduction in withdrawal severity by treatment with choline during the habituation to morphine indicates an inhibition of the development of dependence rather than mere suppression of the signs during withdrawal, which supports the view that a derangement of cholinergic function is a factor in the morphine abstinence syndrome.
- Type
- article
- Published
- 1975-04-01
- Cited by
- 31
- References
- 0
- OpenAlex
- https://openalex.org/W1923204797
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38396548
Keywords
Abstinence Syndrome, Habituation, Cholinergic, Morphine, Anticholinergic
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- Morphine tolerance and physical dependence: influence of cholinergic agonists and antagonists.
- Effects of naloxone and acetylcholine on medial thalamic and cortical units in naive and morphine dependent rats.
- Morphine withdrawal response and central cholinergic activity
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