Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
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Summary
The genetic signatures distinguished clinically distinct groups of oligoastrocytoma patients, which usually present a diagnostic challenge, and were associated with differences in clinical outcome even among individual tumor types.
- Type
- article
- Published
- 2012-07-01
- Cited by
- 575
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1921809757
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15452724
Keywords
ATRX, Medicine, Grossman, Gerontology, Mutation
References
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- Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
Cited by
- Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas.
- Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail
- A Novel, Diffusely Infiltrative Xenograft Model of Human Anaplastic Oligodendroglioma with Mutations in FUBP1, CIC, and IDH1
- CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.
- Molecular genetics of gliomas.
- New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma
- The Role of Histone Modifications and Telomere Alterations in the Pathogenesis of Diffuse Gliomas in Adults and Children
- Glioma biology and molecular markers.
- IDH mutation-specific radiomic signature in lower-grade gliomas
- Emerging drug profile: Krebs cycle and cancer: IDH mutations and therapeutic implications
- Driving Brain Tumorigenesis: Generation and Biological Characterization of a Mutant IDH1 Mouse Model
- ATRX loss-of-function in mouse neuroprogenitor cells as a model of early events in gliomagenesis
- Regulation of Imprinted Genes in the brain by the ATRX Chromatin Remodeling Protein
- Molecular Regulation of Vascular Abnormalization and Its Role in Glioma
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- Glioblastoma: pathology, molecular mechanisms and markers
- The Epigenetic Regulators ATRX and CTCF are Required for Mouse Neuroprogenitor Cell Survival and Brain Development
- Molecular classification of diffuse gliomas.
- Quelle est la place de la biologie moléculaire en neuropathologie tumorale en 2015
- Molecular–genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort
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