Neamine and 2‐deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain
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Summary
To assess the antinociceptive activity of the neomycin derivatives neamine and 2‐deoxystreptamine following intraspinal administration in rats, a novel drug-like substance was developed which blocks the ability of the latter to bind to the receptors of the immune system.
- Type
- article
- Published
- 2015-09-17
- Cited by
- 2
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1918476875
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25668995
Keywords
Neomycin, Neuropathic pain, Nociception, Neuroscience, Anesthesia
References
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- The pain of pain: challenges of animal behavior models.
- An industry perspective on the role and utility of animal models of pain in drug discovery.
- Antinociception induced by intracerebroventricular or intrathecal administration of gentamicin in rats.
- Antinociceptive potency of intrathecal morphine in the rat tail flick test: a comparative study using acute lumbar catheter in rats with or without a chronic atlanto-occipital catheter.
- Nitrogen-15 nuclear magnetic resonance spectroscopy of neomycin B and related aminoglycosides
- A method to perform direct transcutaneous intrathecal injection in rats.
- A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
- Analgesic effects of centrally administered aminoglycoside antibiotics in mice.
- Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity.
- Characterization of a rat model of incisional pain
- Antinociception induced by intraperitoneal injection of gentamicin in rats and mice
- Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule
- Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control
- Involvement of calcium in pain and antinociception.
- Neuropharmacological characterization of voltage-sensitive calcium channels: possible existence of neomycin-sensitive, omega-conotoxin GVIA- and dihydropyridines-resistant calcium channels in the rat brain.
- Antibiotic blockade of neuromuscular function.
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