An apparent relationship between mistranslation and an altered leucyl-tRNA synthetase in a conditional lethal mutant of Neurospora crassa.
Explore this paper's citation graph
Summary
The data obtained suggest that the 45208t phenotype results from a decrease in the fidelity with which leucine is incorporated into protein probably as a consequence of the production of a leucyl-tRNA synthetase with altered substrate binding properties.
- Type
- article
- Published
- 1967-03-01
- Cited by
- 44
- References
- 8
- Access
- Open access
- OpenAlex
- https://openalex.org/W1916812965
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2800655
Keywords
Neurospora crassa, Biology, Neurospora, Mutant, Genetics
References
- Purification and characterization of a TPN-specific glutamic acid dehydrogenase Neurospora crassa.
- A summary of linkage studies in maize
- The regulation of synthesis of leucine biosynthetic enzymes in Neurospora.
- A Plating Method for Genetic Analysis in Neurospora.
- Interspecies aminoacyl-sRNA formation: fractionation of Neurospora enzymes involved in anomalous aminoacylation.
- A NEW ASSAY METHOD FOR AMINO ACID ACTIVATING ENZYMES1
Cited by
- Biological and biochemical effects of phenylalanine analogs.
- Genetics and biochemistry of morphogenesis in Neurospora.
- Stability of the cellular translation process.
- Screening of Escherichia coli Temperature-sensitive Mutants by Pretreatment with Glucose Starvation
- Aminoacyl-tRNA Synthetases: Some Recent Results and Achievements
- Osmotic Remedial Response in a Galactose-negative Mutant of Saccharomyces cerevisiae
- Mutants of Escherichia coli Unable to Make Protein at 42 C
- Biochemical comparison of the Neurospora crassa wild-type and the temperature-sensitive leucine-auxotroph mutant leu-5. Detailed kinetic comparison of the leucyl-tRNA synthetases.
- Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locus.
- Thermal Death of Temperature-Sensitive Lysyl- and Tryptophanyl-Transfer Ribonucleic Acid Synthetase Mutants of Bacillus subtilis: Effect of Culture Medium and Developmental Stage
- The stability of the translation apparatus.
- Biochemical genetic studies of cycloheximide resistance in Neurospora crassa
- Increased mitochondrial leucyland phenylalanyl-tRNA synthetase activity as a result of inhibition of mitochondrial protein synthesis
- A structural gene for seryl-tRNA synthetase in Escherichia coli K12.
- Temperature-sensitivity of the expression of resistance to Puccinia graminis conferred by the Sr15, Sr9b and Sr14 genes in wheat
- Partial purification and characterization of two peptidases from Neurospora crassa.
- Sequence of the met-10+ locus of Neurospora crassa: homology to a sequence of unknown function in Saccharomyces cerevisiae chromosome 8.
- Increased aminoacylation of tRNA as a function of the Abnormal abdomen genotype of Drosophila melanogaster
- Protein turnover in relation to Orgel's error theory of ageing
- Ageing of Clones of Mammalian Cells
Related papers
- Altered species of mitochondrial transfer RNA associated with the mi-1 cytoplasmic mutation in Neurospora crassa.
- Investigations of some "unknown" mutants of Neurospora crassa
- Light-induced dephosphorylation of a 33 kDa protein in the wild-type strain of Neurospora crassa: the regulatory mutants wc-1 and wc-2 are abnormal.
- The effect of mutation on ribonucleic acid, protein and ribonuclease formation in Neurospora crassa
- Rapid loss of a novel phenylalanyl-tRNA on germination of Neurospora crassa conidia
- Method for identification of intracellular free flavin species in the photosensitive fungus Neurospora crassa.
- Thiamine Metabolism in Neurospora crassa
- Genetical and Biochemical Studies of Histidine-Requiring Mutants of Neurospora Crassa. II. Evidence concerning Heterogeneity among Hist-3 Mutants.
- Photomorphogenesis in the hypogeous fungus Tuber borchii: isolation and characterization of Tbwc-1, the homologue of the blue-light photoreceptor of Neurospora crassa.