Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence
Explore this paper's citation graph
Summary
This study demonstrated that macrophage tropism alone is not sufficient for the development of neurological disease and showed that additional sequences derived from the transmembrane portion of envelope and/or nef confer neurovirulence.
- Type
- article
- Published
- 1997-08-01
- Cited by
- 154
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W1909519734
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2488506
Keywords
Virology, Simian immunodeficiency virus, Biology, Tropism, Tissue tropism
References
- Effects of initiation of 3'-azido,3'-deoxythymidine (zidovudine) treatment at different times after infection of rhesus monkeys with simian immunodeficiency virus.
- Pathogenesis of caprine arthritis encephalitis virus. Cellular localization of viral transcripts in tissues of infected goats.
- Neurological complications of HIV infection.
- Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.
- Complex determinants of macrophage tropism in env of simian immunodeficiency virus
- Regulation of lymphocyte homing into the brain during viral encephalitis at various stages of infection.
- Analysis of envelope changes acquired by SIVmac239 during neuroadaption in rhesus macaques.
- Cognitive and motor impairments associated with SIV infection in rhesus monkeys.
- Simian immunodeficiency virus—induced meningoencephalitis: Natural history and retrospective study
- Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.
- The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.
- Human immunodeficiency virus infection in microglia: Correlation between cells infected in the brain and cells cultured from infectious brain tissue
- Role of Secretion and Bulk Flow of Brain Interstitial Fluid in Brain Volume Regulation
- Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host
- HIV dementia: Incidence and risk factors
- Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.
- Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDS
- Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus
- Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques
- Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys.
Cited by
- The mechanisms of neuronal damage in retroviral infections of the nervous system.
- Retroviral diseases of the nervous system: pathogenic host response or viral gene-mediated neurovirulence?
- Simian immunodeficiency virus encephalitis: analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples.
- Caspase-mediated apoptosis and cell death of rhesus macaque CD4+ T-cells due to cryopreservation of peripheral blood mononuclear cells can be rescued by cytokine treatment after thawing.
- Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis.
- Variation of Macrophage Tropism among HIV-1 R5 Envelopes in Brain and Other Tissues
- Unraveling the pathogenesis of HIV peripheral neuropathy: insights from a simian immunodeficiency virus macaque model.
- RELATIONSHIP BETWEEN SYSTEMIC AND CENTRAL NERVOUS SYSTEM MONOCYTE/MACROPHAGE INFECTION IN SIMIAN IMMUNODEFICIENCY VIRUS ENCEPHALITIS
- ANALYSIS OF NEUROPATHOGENESIS ASSOCIATED WITH SIMIAN IMMUNODEFICIENCY VIRUS INFECTION THROUGH DIFFERENTIAL GENE EXPRESSION STUDIES
- The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System
- Restriction of macrophage infection during HIV and SIV infection: The role of antibodies and coreceptor use plasticity in enforcing CD-dependent entry and shaping tropism in vivo
- The blood-brain barrier and AIDS.
- Simian immunodeficiency virus model of HIV-induced central nervous system dysfunction.
- Pathogenesis of simian immunodeficiency virus pneumonia: an immunopathological response to virus.
- Cell Cycle Proteins Exhibit Altered Expression Patterns in Lentiviral-Associated Encephalitis
- Human Immunodeficiency Virus Type 1 Envelope-Mediated Neuronal Death: Uncoupling of Viral Replication and Neurotoxicity
- HIV-1 Tat Molecular Diversity and Induction of TNF-α: Implications for HIV-Induced Neurological Disease
- CD4+ T Cells Support Production of Simian Immunodeficiency Virus Env Antibodies That Enforce CD4-Dependent Entry and Shape Tropism In Vivo
- Simian fetal brain progenitor cells for studying viral neuropathogenesis
- A single amino acid change and truncated TM are sufficient for simian immunodeficiency virus to enter cells using CCR5 in a CD4-independent pathway.
Related papers
- A novel system to study adenovirus tropism to normal and malignant colon tissues.
- Causal relationships between HIV-1 coreceptor utilization, tropism, and pathogenesis in human thymus.
- Advance in Molecular Mechanism of Infectious Bronchitis Virus Infection
- Determination of the factors responsible for host tropism of SARS-CoV-2-related bat coronaviruses
- Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice.
- A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism
- Definition of the range and distribution of human immunodeficiency virus macrophage tropism using PCR-based infectivity measurements.
- Genotypic Prediction of Tropism of Highly Diverse HIV-1 Strains from Cameroon
- Comparison of tissue tropism and host response to enteric and respiratory enteroviruses