Use of random systematic mutagenesis to generate viable human rhinovirus 14 chimeras displaying human immunodeficiency virus type 1 V3 loop sequences
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Summary
The random systematic mutagenesis methodology described should be generally useful for the rapid transplantation of foreign sequences into viral coat and other proteins to produce libraries containing members with the desired properties.
- Type
- article
- Published
- 1994-01-01
- Cited by
- 29
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1909337069
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12969942
Keywords
Biology, Rhinovirus, Virology, Mutagenesis, Antigenicity
References
- In vitro synthesis of an infectious RNA from cDNA clones of human rhinovirus type 14
- Textbook of Pediatric Infectious Diseases
- Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14
- Evidence for at least two dominant neutralization antigens on human rhinovirus 14
- Mapping of a neutralizing antigenic site of Coxsackievirus B4 by construction of an antigen chimera
- An antigen chimera of poliovirus induces antibodies against human papillomavirus type 16
- Chimeric polioviruses that include sequences derived from two independent antigenic sites of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies against FMDV in guinea pigs
- Poliovirus chimeras expressing sequences from the principal neutralization domain of human immunodeficiency virus type 1
- An engineered poliovirus chimaera elicits broadly reactive HIV-1 neutralizing antibodies
- Construction and characterization of a poliovirus/rhinovirus antigenic hybrid.
- Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant.
- Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen.
- Structure of a human common cold virus and functional relationship to other picornaviruses
- Infectious enveloped RNA virus antigenic chimeras.
- A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120.
- Design and construction of rhinovirus chimeras incorporating immunogens from polio, influenza, and human immunodeficiency viruses.
- Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.
- Immunogenicity and antigenicity of chimeric picornaviruses which express hepatitis A virus (HAV) peptide sequences: evidence for a neutralization domain near the amino terminus of VP1 of HAV.
- Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 A.
- A cassette vector for the construction of antigen chimaeras of poliovirus.
Cited by
- Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 (HIV-1) V3 Loop Chimeras from a Combinatorial Library Induce Potent Neutralizing Antibody Responses against HIV-1
- Expanding baculovirus surface display. Modification of the native coat protein gp64 of Autographa californica NPV.
- Autonomous parvovirus and densovirus gene vectors.
- Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines
- Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach
- Vaccination with an Adenoviral Vector That Encodes and Displays a Retroviral Antigen Induces Improved Neutralizing Antibody and CD4+ T-Cell Responses and Confers Enhanced Protection
- HIV/AIDS Vaccine Development: Challenges, Progress and Future Directions
- Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes.
- Generation of bioactive peptides by biological libraries.
- HIV Antigen Incorporation within Adenovirus Hexon Hypervariable 2 for a Novel HIV Vaccine Approach
- Relationship between Antigenicity and Immunogenicity of Chimeric Hepatitis B Virus Core Particles Carrying HIV Type 1 Epitopes
- Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses
- Antigenic Characteristics of Rhinovirus Chimeras Designed in silico for Enhanced Presentation of HIV-1 gp41 Epitopes
- A Disulfide-Bound HIV-1 V3 Loop Sequence on the Surface of Human Rhinovirus 14 Induces Neutralizing Responses against HIV-1
- Peptides as drugs: from screening to application.
- Probing the ability of the coat and vertex protein of the membrane-containing bacteriophage PRD1 to display a meningococcal epitope.
- Attenuated Mengo virus: a new vector for live recombinant vaccines
- Current progress in the development of a prophylactic vaccine for HIV-1
- Broad Neutralization of Human Immunodeficiency Virus Type 1 (HIV-1) Elicited from Human Rhinoviruses That Display the HIV-1 gp41 ELDKWA Epitope
- Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1
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