Toll‐like receptors expressed on embryonic macrophages couple inflammatory signals to iron metabolism during early ontogenesis
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Summary
It is shown that embryonic phagocytes express protein machinery that is essential for the recycling of cellular iron and that this expression can be regulated by TLR engagement in a MyD88‐dependent manner, leading to typical inflammatory M1 responses.
- Type
- article
- Published
- 2014-05-01
- Cited by
- 11
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1907022417
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205790626
Keywords
Biology, Cell biology, Proinflammatory cytokine, TLR2, Innate immune system
References
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- Toll-like receptors: critical proteins linking innate and acquired immunity
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- Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain.
- Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
- The immune self: theory or metaphor?
- Iron imports. IV. Hepcidin and regulation of body iron metabolism.
- Iron and the immune system
- Fluorescence analysis of the labile iron pool of mammalian cells.
- Three pathways to mature macrophages in the early mouse yolk sac.
- TLR3 immunity to infection in mice and humans
- Two independent pathways of maternal cell transmission to offspring: through placenta during pregnancy and by breast‐feeding after birth
- Systemic and cellular consequences of macrophage control of iron metabolism.
- Toll‐like receptors: key activators of leucocytes and regulator of haematopoiesis
- Bioinformatics and Computational Biology Solutions Using R and Bioconductor
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells
- Blood island formation: longstanding observations and modern interpretations.
Cited by
- Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production
- Early hematopoiesis and macrophage development
- Micronutrients and many important factors that affect the physiological functions of toll-like receptors
- A role for macrophages in hematopoiesis in the embryonic head.
- Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
- A comprehensive mechanistic review insight into the effects of micronutrients on toll-like receptors functions.
- mRNAs of Genes of Toll-Like Receptors are Expressed in Human Fetal Eye Tissues
- Deletion of TLR2+ erythro‐myeloid progenitors leads to embryonic lethality in mice
- Toll-like receptors ligand immunomodulators for the treatment congenital diaphragmatic hernia
- Association of the rs8193046 polymorphism of the TLR4 gene with the elemental composition of the blood serum of red steppe cows
- Toll-Like Receptor 2 Expression on c-kit+ Cells Tracks the Emergence of Definitive Hematopoietic Progenitors in a Pre-Circulation Embryo
- progenitor cell production Inflammatory signaling regulates embryonic hematopoietic stem and Material
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