Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor.
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Summary
A CCR5-deficient mouse model generated by targeted deletion of the ccr5 gene showed reduced efficiency in clearance of Listeria infection and exert a protective effect against LPS-induced endotoxemia, reflecting a partial defect in macrophage function.
- Type
- article
- Published
- 1998-04-15
- Cited by
- 272
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1905677550
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32830377
Keywords
Immune system, Biology, Chemokine, Chemokine receptor, Immunology
References
- HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
- Compartmentalized expression of RANTES in a murine model of endotoxemia.
- Molecular characterization of two murine eosinophil beta chemokine receptors.
- Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk
- Macrophage inflammatory protein 1 modulates macrophage function.
- Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia.
- Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.
- Expression cloning of new receptors used by simian and human immunodeficiency viruses
- An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.
- Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
- CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
- Characterisation of the RANTES/MIP-1 alpha receptor (CC CKR-1) stably transfected in HEK 293 cells and the recombinant ligands.
- Identification of a major co-receptor for primary isolates of HIV-1
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
- A new class of membrane-bound chemokine with a CX3C motif
- Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta
- Molecular cloning and functional expression of a new human CC-chemokine receptor gene.
- Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α*
- Chemokines, leukocyte trafficking, and inflammation.
- Macrophages as a source of HIV during opportunistic infections.
Cited by
- Chemokines and their receptors in infectious disease
- Aberrant Macrophage and Neutrophil Population Dynamics and Impaired Th1 Response to Listeria monocytogenesin Colony-Stimulating Factor 1-Deficient Mice
- Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis.
- Immunobiology of epithelial chemokines in the intestinal mucosa.
- Role of the Chemokine Receptor CXCR3 in Human Mast Cell Degranulation and Signalling
- Functional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System
- Cytokine Knockouts in Inflammation
- Regulation of Granuloma Formation in Mouse Models of Tuberculosis
- HIV Coreceptors and Chemokines as Therapeutic Targets Against HIV/AIDS
- On the intracellular trafficking of CC chemokine receptor 5
- Mécanismes de progression des carcinomes de la prostate et recherche de nouveaux facteurs pronostiques
- CCR5 Regulates High Dose Oral Tolerance by Modulating CC Chemokine Ligand 2 Levels in the GALT1
- Chemokines as regulators of T cell differentiation
- QSAR modeling of CCR5 receptor antagonists using artificial neural network
- Chemokines in immunity.
- CCR5-Δ32 mutation is strongly associated with primary sclerosing cholangitis
- Differential Roles for CCR5 Expression on Donor T Cells during Graft-versus-Host Disease Based on Pretransplant Conditioning1
- Factores inmunitarios protectivos del huésped contra la infección por el VIH-1 y la progresión a SIDA: quimiocinas y sus receptores.
- CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
- STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13.
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