Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis.
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Summary
Steady decreasing sequencing costs are increasing the appeal of WGS as an alternative approach for detecting complex patterns of pyrazinamide resistance in MDR-TB.
- Type
- article
- Published
- 2015-09-01
- Cited by
- 29
- References
- 19
- OpenAlex
- https://openalex.org/W1900173796
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11249000
Keywords
Pyrazinamide, Mycobacterium tuberculosis, Biology, Whole genome sequencing, Microbiology
References
- Role of rpsA Gene Sequencing in Diagnosis of Pyrazinamide Resistance
- Discrepant results between pyrazinamide susceptibility testing by the reference BACTEC 460TB method and pncA DNA sequencing in patients infected with multidrug-resistant W-Beijing Mycobacterium tuberculosis strains.
- Mauve: multiple alignment of conserved genomic sequence with rearrangements.
- Whole Genome Sequencing Reveals Complex Evolution Patterns of Multidrug-Resistant Mycobacterium tuberculosis Beijing Strains in Patients
- Whole-Genome Sequencing for Rapid Susceptibility Testing of M. tuberculosis
- Purification and characterization of Mycobacterium tuberculosis KatG, KatG(S315T), and Mycobacterium bovis KatG(R463L).
- Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis
- Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis
- Added value of whole-genome sequencing for management of highly drug-resistant TB
- Automated High-Throughput Genotyping for Study of Global Epidemiology of Mycobacterium tuberculosis Based on Mycobacterial Interspersed Repetitive Units
- Prevalence and Molecular Characteristics of Drug-Resistant Mycobacterium tuberculosis in Hunan, China
- Molecular Detection of Mutations Associated with First- and Second-Line Drug Resistance Compared with Conventional Drug Susceptibility Testing of Mycobacterium tuberculosis
- Association between pncA Gene Mutations, Pyrazinamidase Activity, and Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis
- Mycobacterium tuberculosis Pyrazinamide Resistance Determinants: a Multicenter Study
- Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid
- Pyrazinamide Resistance among South African Multidrug-Resistant Mycobacterium tuberculosis Isolates
- Epidemiology of pyrazinamide-resistant tuberculosis in the United States, 1999-2009
- Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay
- Systems approach to tuberculosis vaccine development
Cited by
- Challenges in childhood tuberculosis
- The Broad Street Pump
- dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains
- The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee.
- Mycobactérium tuberculosis and non tuberculous Mycobacteria in the French Departments of the Americas and in the Caribbean : studying epidemiological aspects and transmission using molecular tools and database comparison
- Genetic determinants and evolution of drug resistance in Mycobacterium tuberculosis in Vietnam : toward new diagnostic tools
- Identification of M. tuberculosis pncA gene single nucleotide polymorphisms conferring resistance to pyrazinamide.
- Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance-associated mutations in clinical isolates
- Genotypic characterization of pyrazinamide resistance in Mycobacterium tuberculosis isolated from Lusaka, Zambia.
- Dissecting whole-genome sequencing-based online tools for predicting resistance in Mycobacterium tuberculosis: can we use them for clinical decision guidance?
- Insights into the processes that drive the evolution of drug resistance in Mycobacterium tuberculosis
- Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase
- Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
- Diagnosis of TB: From conventional to modern molecular protocols.
- Genome rearrangements in Escherichia coli during de novo acquisition of resistance to a single antibiotic or two antibiotics successively
- Tuberculosis: new era for diagnosis and surveillance using whole-genome sequencing-based approaches
- PARMAP: A Pan-Genome-Based Computational Framework for Predicting Antimicrobial Resistance
- Value of routine whole genome sequencing for Mycobacterium tuberculosis drug resistance detection.
- Revisiting the methods for detecting Mycobacterium tuberculosis: what has the new millennium brought thus far?
- Drug resistance prediction for Mycobacterium tuberculosis with reference graphs
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