Isolated Limb Infusion as a Model to Test New Agents to Treat Metastatic Melanoma
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Summary
This review will focus on regional therapy for in‐transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help develop insights to more rationally design systemic therapy trials.
- Type
- review
- Published
- 2013-11-20
- Cited by
- 11
- References
- 119
- Access
- Open access
- OpenAlex
- https://openalex.org/W1895086931
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9135225
Keywords
Medicine, Melanoma, Metastatic melanoma, Disease, Animal model
References
- Disease-associated Bias in T Helper Type 1 (Th1)/Th2 CD4+ T Cell Responses Against MAGE-6 in HLA-DRB10401+ Patients With Renal Cell Carcinoma or Melanoma
- The role of B-RAF in melanoma
- Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma
- Regional perfusion with cis-platinum and dacarbazine.
- New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating agents in combination with guanine analogues to abrogate drug resistance.
- Melphalan-induced up-regulation of B7–1 surface expression on normal splenic B cells
- Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity
- Gene Expression Signatures as a Guide to Treatment Strategies for In-Transit Metastatic Melanoma
- Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia.
- Treatment of Metastatic Melanoma: An Overview
- Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
- Src family kinases in tumor progression and metastasis
- Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.
- Involvement of the mismatch repair system in temozolomide-induced apoptosis.
- High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.
- Src kinases as therapeutic targets for cancer
- Dechlorination of L-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content.
- Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.
- B7-2 expression on tumor cells is important for the acquisition of cytotoxic T lymphocyte activity by spleen cells from low-dose-melphalan-treated MOPC-315 tumor bearers via a mechanism that requires either B7-1 or B7-2 expression on host antigen-presenting cells
- Acidosis plus melphalan induces nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model.
Cited by
- The Role of Regional Therapies for in-Transit Melanoma in the Era of Improved Systemic Options
- Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency
- Regional aspects of melanoma diagnosis and treatment
- A Translational Pathway for Recombinant Adeno-Associated Virus Human Gene Therapy: From Target Identification and Animal Modeling of the Disease to Non-Human Primate and Human Studies
- Molecular Aspects of the Isolated Limb Infusion Procedure
- A phase 1 study of intra-arterial CBL0137 in extremity melanomas and sarcomas
- Isolated Limb Infusion for Melanoma
- University of Groningen Regional aspects of melanoma diagnosis and treatment
- Hyperthermic Regional Perfusion for Melanoma of the Limbs
- Isolated Limb Infusion for Melanoma
- Chapter 14 – Gene Therapy
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- Supplementary Figures S1-S2 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases