Metalloendoprotease cleavage triggers gelsolin amyloidogenesis
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Summary
Proteolysis by MT1‐MMP‐like proteases proximal to the unique chemical environment of the ECM offers an explanation for the tissue‐specific deposition observed in FAF and provides critical insight into new therapeutic strategies.
- Type
- article
- Published
- 2005-12-07
- Cited by
- 66
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1890188140
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6575854
Keywords
Biology, Gelsolin, Cleavage (geology), Cell biology, Computational biology
References
- An automated multidimensional protein identification technology for shotgun proteomics.
- Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin.
- Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
- Membrane type-matrix metalloproteinases (MT-MMP).
- Muscle is the major source of plasma gelsolin.
- Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide.
- Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.
- Protein Folding and Disease: a view from the first Horizon Symposium
- Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease.
- Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein
- Demonstration of a circulating 65K gelsolin variant specific for familial amyloidosis, Finnish type.
- Low Molecular Weight Inhibitors in Corneal Ulceration a
- Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns.
- Review: history of the amyloid fibril.
- Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization
- The amyloidogenicity of gelsolin is controlled by proteolysis and pH.
- Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide.
- Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP*
- Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.
- Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.
Cited by
- Gender differences in the clinical course of Finnish gelsolin amyloidosis
- Hereditary gelsolin amyloidosis.
- Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids
- Rare Types of Amyloidosis and their Pathogenesis: Targets for Innovative Therapy
- Perinnöllisen gelsoliiniamyloidoosin proteiiniekspression poikkeavuudet ja amyloidin muodostuksen estäminen
- Amyloid diseases at old age : a pathological, epidemiological, and genetic study
- Multifunctional roles of gelsolin in health and diseases
- Neuropatie amiloidi familiari
- Formation of Pmel17 Amyloid Is Regulated by Juxtamembrane Metalloproteinase Cleavage, and the Resulting C-terminal Fragment Is a Substrate for γ-Secretase*
- Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?
- Gelsolin Amyloidosis: Genetics, Biochemistry, Pathology and Possible Strategies for Therapeutic Intervention
- N-Terminal Region of Gelsolin Induces Apoptosis of Activated Hepatic Stellate Cells by a Caspase-Dependent Mechanism
- Excessive fibrinolysis in AL-amyloidosis is induced by urokinae-type plasminogen activator from bone marrow plasma cells
- Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases.
- Simulated pathogenic conformational switch regions matched well with the biochemical findings
- Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model.
- Disorder-to-order conformational transitions in protein structure and its relationship to disease
- Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin
- Heparin Binds 8 kDa Gelsolin Cross-β-Sheet Oligomers and Accelerates Amyloidogenesis by Hastening Fibril Extension
- Outcome of renal transplant in hereditary gelsolin amyloidosis.
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