RUNX2: A Master Bone Growth Regulator That May Be Involved in the DNA Damage Response
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Summary
Data suggest the involvement of RUNX2 in cellular DNA damage response (DDR), which is particularly important in osteogenesis as the process of osteoblast differentiation is associated with increasing oxidative stress, however, the mechanism underlying DDR involvement of RunX2 is unknown.
- Type
- review
- Published
- 2015-05-01
- Cited by
- 60
- References
- 114
- OpenAlex
- https://openalex.org/W1868917636
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23738205
Keywords
RUNX2, Biology, DNA damage, Transcription factor, Cell cycle
References
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Cited by
- Role of RUNX2 in Breast Carcinogenesis
- MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2
- Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway
- Runx2 /DICER/miRNA Pathway in Regulating Osteogenesis
- BST2 Mediates Osteoblast Differentiation via the BMP2 Signaling Pathway in Human Alveolar-Derived Bone Marrow Stromal Cells
- Micromolar Levels of Sodium Fluoride Promote Osteoblast Differentiation Through Runx2 Signaling
- Radiographic and Histological Evaluation of the Healing of Extraction Sockets Filled With Bovine-Derived Xenograft: An Experimental Study in Rats
- Posttranscriptional Interaction Between miR‐450a‐5p and miR‐28‐5p and STAT1 mRNA Triggers Osteoblastic Differentiation of Human Mesenchymal Stem Cells
- RUNX in Invertebrates.
- Puerarin promotes the viability and differentiation of MC3T3‑E1 cells by miR‑204‑regulated Runx2 upregulation.
- XRCC2-Deficient Cells are Highly Sensitive to 5-Fluorouracil in Colorectal Cancer
- Calcium hydroxide regulates transcription of the bone sialoprotein gene via a calcium‐sensing receptor in osteoblast‐like ROS 17/2.8 cells
- Periostin has a protective role in melatonin‑induced cell apoptosis by inhibiting the eIF2α‑ATF4 pathway in human osteoblasts.
- TRAFICKING PROTEIN PARTICLE COMPLEX (TRAPPC) -9:A NOVEL PROTEIN REGULATOR OF NF-kB MEDIATED BONE FORMATION AND RESORPTION
- Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis
- Endoplasmic reticulum stress regulates mechanical stress-induced ossification of posterior longitudinal ligament
- The interaction between RUNX2 and core binding factor beta (CBFβ) as a potential therapeutic target in canine osteosarcoma
- Melatonin Attenuates AlCl3-Induced Apoptosis and Osteoblastic Differentiation Suppression by Inhibiting Oxidative Stress in MC3T3-E1 Cells
- Kaempferol promotes bone formation in part via the mTOR signaling pathway
- MiR-122 inhibits cell proliferation and induces apoptosis by targeting runt-related transcription factors 2 in human glioma.
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