Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q.
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Summary
The results indicate that endothelin-promoted ERK/MAPK activation criticially depends on palmitoylation but not on phosphorylation of ET receptors, and that the G(alpha)q/phospholipase C-beta/Ca2+/Src signaling cascade is necessary for efficient coupling of ET receptor to the ERK /MAPK pathway.
- Type
- article
- Published
- 2001-10-15
- Cited by
- 64
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1866179064
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10595142
Keywords
MAPK/ERK pathway, Cell biology, Kinase, Tyrosine phosphorylation, Biology
References
- Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.
- Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.
- Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells.
- c-Src Activation Plays a Role in Endothelin-dependent Hypertrophy of the Cardiac Myocyte*
- A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts.
- Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.
- Role of palmitoylation of conserved cysteine residues of luteinizing hormone/human choriogonadotropin receptors in receptor down-regulation.
- Mitogenic and receptor activities of human growth hormone 108-129.
- Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
- Growth Factor Activity of Endothelin-1 in Primary Astrocytes Mediated by Adhesion-Dependent and -Independent Pathways
- Endothelin‐1[1–31], acting as an ETA‐receptor selective agonist, stimulates proliferation of cultured rat zona glomerulosa cells
- Truncation of the receptor carboxyl terminus impairs membrane signaling but not ligand binding of human ETB endothelin receptor.
- Subtype-specific desensitization of human endothelin ETA and ETB receptors reflects differential receptor phosphorylation.
- Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
- Ligand-induced Phosphorylation/Dephosphorylation of the Endogenous Bradykinin B2 Receptor from Human Fibroblasts*
- Differentiation of Embryonal Carcinoma Cells to a Neural or Cardiomyocyte Lineage Is Associated with Selective Expression of Endothelin Receptors (*)
- Post-translational Modifications of Endothelin Receptor B from Bovine Lungs Analyzed by Mass Spectrometry*
- Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G–protein coupled receptor–EGF receptor transactivation pathway
- Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
- Regulation of transmembrane signaling by receptor phosphorylation.
Cited by
- Semliki Forest virus vectors for overexpression of 101 G protein-coupled receptors in mammalian host cells.
- Therapeutic potential of endothelin receptor type A and bradykinin receptor B1 dual antagonism in osteoarthritis treatment
- Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.
- Receptor cross talk in arsenic-impaired fat metabolism
- Analysis of the mammary gland specific effect of endothelin-1 in transgenic mice
- Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems
- Cardiovascular risk factors regulate the expression of vascular endothelin receptors.
- Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line.
- "Ins and outs" of seven-transmembrane receptor signalling to ERK.
- The Extracellular N Terminus of the Endothelin B (ETB) Receptor Is Cleaved by a Metalloprotease in an Agonist-dependent Process*
- Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances β-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation*
- Blocage de l'endothline dans la sclrodermie systmique : rationnel et bnfice clinique
- Calmodulin-dependent binding to the NHE1 cytosolic tail mediates activation of the Na+/H+ exchanger by Ca2+ and endothelin.
- Possible autocrine regulation of chromaffin cell activity in adrenal glands of the frog by endothelin-1-induced serotonin release.
- Gαq controls rheumatoid arthritis via regulation of Th17 differentiation
- Lipid rafts Published, JLR Papers in Press, February 1, 2003. DOI 10.1194/jlr.R200021-JLR200
- Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors.
- Palmitoylation of the Human Prostacyclin Receptor
- Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells
- The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling.
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