Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor.
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Summary
The NVU has enabled in vitro modeling of the BBB using all human cell types and sampling effluent from both sides of the barrier, and has been validated with both fluorescein isothiocyanate-dextran diffusion and transendothelial electrical resistance.
- Type
- article
- Published
- 2015-10-26
- Cited by
- 360
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1847104216
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205209229
Keywords
Blood–brain barrier, Tight junction, Microfluidics, Biophysics, Biomedical engineering
References
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- Organs-on-a-Chip: A Focus on Compartmentalized Microdevices
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- Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model
- Organs-on-chips: breaking the in vitro impasse.
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- Ascorbic Acid Prevents Increased Endothelial Permeability Caused by Oxidized Low Density Lipoprotein
- Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
- Microfabricated scaffold-guided endothelial morphogenesis in three-dimensional culture
- Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).
- Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood–brain barrier
Cited by
- Microdevice Platform for In Vitro Nervous System and Its Disease Model
- Engineering the human blood-brain barrier in vitro
- Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling
- Hollow Fiber Bioreactor Technology for Tissue Engineering Applications
- Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems.
- Complex Tissue and Disease Modeling using hiPSCs.
- Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
- Microfluidic-based biomimetic models for life science research
- Microfluidic organ-on-chip technology for blood-brain barrier research
- Bioengineered cell culture systems of central nervous system injury and disease.
- Direct quantification of transendothelial electrical resistance in organs-on-chips.
- Physiologically Relevant Human Tissue Models for Infectious Diseases
- An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development.
- Microfluidic Blood-Brain Barrier Model Provides In Vivo-Like Barrier Properties for Drug Permeability Screening
- Microfluidic-Based Multi-Organ Platforms for Drug Discovery
- Engineered Microvessels for the Study of Human Disease.
- Ultrathin Polymer Membranes with Patterned, Micrometric Pores for Organs-on-chips
- New experimental models of the blood-brain barrier for CNS drug discovery
- Protein thermostability engineering
- Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling
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