Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor.

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Summary

The NVU has enabled in vitro modeling of the BBB using all human cell types and sampling effluent from both sides of the barrier, and has been validated with both fluorescein isothiocyanate-dextran diffusion and transendothelial electrical resistance.

Type
article
Published
2015-10-26
Cited by
360
References
62
Access
Open access

Keywords

Blood–brain barrier, Tight junction, Microfluidics, Biophysics, Biomedical engineering

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