Leucovorin plus 5-fluorouracil: an effective treatment for metastatic colon cancer.
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Summary
One patient with prior RT died of neutropenic sepsis after only the three-day load, so it is now recommend only weekly therapy in previously radiated patients, and this regimen should be considered for patients who desire therapy.
- Type
- article
- Published
- 1987-09-01
- Cited by
- 76
- References
- 10
- OpenAlex
- https://openalex.org/W1837458449
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25989361
Keywords
Medicine, Fluorouracil, Regimen, Toxicity, Gastroenterology
References
- Phase I-II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer.
- Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.
- Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid.
- High-dose continuous infusion folinic acid and bolus 5-fluorouracil in patients with advanced colorectal cancer: a phase II study.
- Hepatic artery ligation and portal vein infusion for liver metastases from colon cancer.
- 5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer: a randomized comparison. A Southwest Oncology Group Study.
- Editorial: Large-bowel cancer-The current status of treatment.
- Treatment of advanced colorectal and gastric adenocarcinomas with 5-FU combined with high-dose folinic acid: a pilot study.
- Preliminary analysis of a randomized comparison of 5-fluorouracil versus 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer.
Cited by
- Folinic acid (CF)/5-fluorouracil (FUra) combinations in advanced gastrointestinal carcinomas.
- Systemic chemotherapy in patients with peritoneal carcinomatosis from non colorectal origin.
- Folate metabolites as modulators of antitumor drug activity.
- Clinical experience with CF-FUra.
- Results of cytoreduction followed by HIPEC in carcinomatosis of colorectal origin.
- BIRC7- and RTEL1-knockdown in the human colorectal cancer cell line HT29 with chromosomal 20q amplification : effects on cell proliferation and cell death
- Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
- Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy.
- Fluorouracil: biochemistry and pharmacology.
- Targeted therapies in colorectal cancer: surgical considerations.
- Cytoreduction and hyoerthermic intraperitoneal chemotherapy in peritoneal carcinomastosis of colorectal origin
- Recurrences after Peritoneal Carcinomatosis of Colorectal Origin Treated by Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy: Location, Treatment, and Outcome
- Assessing the clinical significance of drug interactions with fluorouracil in patients with colorectal cancer.
- Use of Epstein-Barr Virus Nuclear Antigen-1 in Targeted Therapy of EBV-Associated Neoplasia
- Enhancement of the antitumor effects of 5-fluorouracil by folinic acid.
- Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer.
- Double modulation of 5-fluorouracil in the treatment of advanced colorectal carcinoma: report of a trial with sequential methotrexate, intravenous (loading dose) folinic acid, 5-fluorouracil, and a literature review.
- Developments of the fluoropyrimidines as inhibitors of thymidylate synthetase: Pharmacologic and clinical aspects
- Phase I study of 5-day continuous infusion fluorodeoxyuridine and high-dose folinic acid with oral hydroxyurea
- Human red blood cell-mediated metabolism of leucovorin [(R,S)5-formyltetrahydrofolate].
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