Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.
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Summary
Osteoblast cell proliferation was decreased, and cytodifferentiation was increased in a dose-dependent manner in cultures treated with the bisphosphonate pamidronate, and the rate of bone formation was also increased in osteoblasts cultured with pamodronate.
- Type
- article
- Published
- 2000-11-01
- Cited by
- 400
- References
- 50
- OpenAlex
- https://openalex.org/W1836348293
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14705171
Keywords
Osteoblast, Bisphosphonate, Bone resorption, Chemistry, Internal medicine
References
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- Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs.
- Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis
- Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment.
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
- Effect of alendronate on cultured normal human osteoblasts.
- Pamidronate treatment in patients with tumor-associated hypercalcemia: pharmacological effects and pharmacokinetics.
- Infusion rate and pharmacokinetics of intravenous pamidronate in the treatment of tumour-induced hypercalcaemia.
- PHARMACOKINETICS OF PAMIDRONATE DISODIUM IN CANCER PATIENTS AFTER A SINGLE INTRAVENOUS INFUSION OF 30‐, 60− OR 90‐mg DOSE OVER 4 OR 24 HOURS
- Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.
- Effects of two novel bisphosphonates on bone cells in vitro.
- Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106.
- Effects of short‐term treatment with the bisphosphonates zoledronate and pamidronate on rat bone: A comparative histomorphometric study on the cancellous bone formed before, during, and after treatment
- Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1.
- Bisphosphonates: from the laboratory to the clinic and back again.
- Development and characterization of a conditionally immortalized human fetal osteoblastic cell line
- Alendronate/Interleukin‐1β Cotreatment Increases Interleukin‐6 in Bone and UMR‐106 Cells: Dose Dependence and Relationship to the Antiresorptive Effect of Alendronate
- The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen‐Containing Bisphosphonates
- The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates.
Cited by
- Zoledronic acid significantly reduces pathologic fractures in patients with advanced-stage prostate cancer metastatic to bone.
- The Effects of Risedronate and Exercise on Osteoporotic Lumbar Rat Vertebrae and Their Sensory Innervation
- Treatment of bisphosphonate-induced osteonecrosis of the jaws with Nd:YAG laser biostimulation
- Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model.
- Effect of bisphosphonates treatment on cytokine imbalance between TH17 and Treg in osteoporosis
- Effect of surfactant concentration on textural characteristics and biomineralization behavior of mesoporous bioactive glasses.
- Bisfosfonatos e osteonecrose dos maxilares
- The isoprenoid biosynthesis pathway and regulation of osteoblast differentiation
- Bisphosphonate Inhibition of Prostate Cancer Cell Invasion, Migration and Cytoskeletal Organization
- Pharmacotherapy of Paget’s Disease of Bone: Focus on Zoledronic Acid
- Effect of Zoledronate on Bone Quality in the Treatment of Aseptic Loosening of Hip Arthroplasty in the Dog
- Effects of Bisphosphonates on the Proliferation and the Alkaline Phosphatase Activity of Human Bone Marrow Derived Mesenchymal Stem Cells
- Novel perspectives to improve the outcome of bone impaction grafting in revision surgery of total hip arthroplasties
- Histochemical evidence of zoledronate inhibiting c-src expression and interfering with CD44/OPN-mediated osteoclast adhesion in the tibiae of mice
- Modifications de la composition et de la structure moléculaire du tissu osseux sous l'influence des bisphosphonates
- Surface modification of titanium and titanium alloys to enhance bone healing
- Drug delivery to the bone-implant interface: Functional hydroxyapatite surfaces and particles
- Enhanced Anchorage of Tissue-Engineered Cartilage Using an Osteoinductive Approach
- Перспективные направления терапии остеоартроза
- Enhancing Quality of Life for Breast Cancer Patients with Bone Metastases
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