Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.

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Summary

Osteoblast cell proliferation was decreased, and cytodifferentiation was increased in a dose-dependent manner in cultures treated with the bisphosphonate pamidronate, and the rate of bone formation was also increased in osteoblasts cultured with pamodronate.

Type
article
Published
2000-11-01
Cited by
400
References
50

Keywords

Osteoblast, Bisphosphonate, Bone resorption, Chemistry, Internal medicine

References

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