The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: analysis of the National Cancer Data Base (NCDB)
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Summary
The authors sought to explore the interplay of these factors with systemic chemotherapy in a large population data set and found that mucinous histology, histologic grade, and stage are important factors in the development of Adenocarcinomas of the appendix.
- Type
- article
- Published
- 2015-10-27
- Cited by
- 176
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W1821021293
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36224493
Keywords
Medicine, Internal medicine, Cancer, Hazard ratio, Oncology
References
- Pseudomyxoma Peritonei of Appendiceal Origin: A Clinicopathologic Analysis of 101 Patients Uniformly Treated at a Single Institution, With Literature Review
- Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin
- Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei".
- Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations.
- Appendiceal adenocarcinoma: Long-term outcomes after surgical therapy
- A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei
- High-Level Microsatellite Instability in Appendiceal Carcinomas
- Primary malignant neoplasms of the appendix
- Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade
- Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade
- Importance of Histologic Subtype in the Staging of Appendiceal Tumors
- Management and prognosis of adenocarcinoma of the appendix
- Appendiceal Mucinous Neoplasms: A Clinicopathologic Analysis of 107 Cases
- Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study.
- Appendiceal neoplasms and pseudomyxoma peritonei: a population based study.
- Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
- Systemic chemotherapy and surgical cytoreduction for poorly differentiated and signet ring cell adenocarcinomas of the appendix.
- Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin
- FOLFOX-4 chemotherapy for patients with unresectable or relapsed peritoneal pseudomyxoma.
- Systemic therapy for advanced appendiceal adenocarcinoma: an analysis from the NCCN Oncology Outcomes Database for colorectal cancer.
Cited by
- Prophylactic hyperthermic intraperitoneal chemotherapy in patients with epithelial appendiceal neoplasms
- Impact of Mucinous Histology on the Prognosis of Stage I–III Adenocarcinomas of the Appendix: a Population-Based, Propensity Score-Matched Analysis
- A Novel Pathology-Based Preoperative Risk Score to Predict Locoregional Residual and Distant Disease and Survival for Incidental Gallbladder Cancer: A 10-Institution Study from the U.S. Extrahepatic Biliary Malignancy Consortium
- The Management and Prognostic Prediction of Adenocarcinoma of Appendix
- Retrospective study of nonmucinous appendiceal adenocarcinomas: role of systemic chemotherapy and cytoreductive surgery
- Survival after resection of appendiceal carcinoma by hemicolectomy and less radical than hemicolectomy: a population‐based propensity score matched analysis
- Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Moderately and Poorly Differentiated Appendiceal Adenocarcinoma: Survival Outcomes and Patient Selection
- Utility of Appendiceal Calcifications Detected on Computed Tomography as a Predictor for an Underlying Appendiceal Epithelial Neoplasm
- Successful Extended Surgery for Mucinous Cystadenocarcinoma of the Appendix with the Right Iliopsoas Muscle Invasion
- Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade
- Grading and staging mucinous neoplasms of the appendix: a case series and review of the literature.
- An Update on the Diagnosis, Grading, and Staging of Appendiceal Mucinous Neoplasms
- Validation of the Recent PSOGI Pathological Classification of Pseudomyxoma Peritonei in a Single-Center Series of 265 Patients Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
- Efficacy of the Gallbladder Cancer Predictive Risk Score Based on Pathological Findings: A Propensity Score-Matched Analysis
- Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study
- Learning Curve, Training Program, and Monitorization of Surgical Performance of Peritoneal Surface Malignancies Centers.
- Genomic Landscape of Appendiceal Neoplasms.
- Low-grade Appendiceal Mucinous Neoplasm Presenting as Adnexal Mass: A Case Report
- Heterogeneous mutational profile and prognosis conferred by TP53 mutations in appendiceal mucinous neoplasms.
- Clinicopathological Criteria Defining Mucinous Appendiceal Tumors from 2476 Appendectomies: a Single-Center Retrospective Study
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