Impact of chromosomal translocations on prognosis in childhood acute lymphoblastic leukemia.
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Summary
Categorization of patients on the basis of chromosomal translocations without attention to the specific abnormality is not useful as a prognostic factor when effective intensive therapy is used to treat childhood ALL with high-risk clinical features.
- Type
- article
- Published
- 1991-12-01
- Cited by
- 47
- References
- 25
- OpenAlex
- https://openalex.org/W1815410165
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10237294
Keywords
Chromosomal translocation, Calla, Medicine, Univariate analysis, Internal medicine
References
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- Philadelphia chromosome positive childhood acute lymphoblastic leukemia.
- Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia.
- Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia
Cited by
- Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
- Prognostic value of tumoral ploidy in a series of spanish patients with acute lymphoblastic leukemia.
- High hyperdiploid childhood acute lymphoblastic leukemia
- TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia.
- Clinical and Biological Implications of Chromosomal Translocations and Ploidy in Childhood Acute Lymphoblastic Leukemia
- Philadelphia chromosome in relapsed childhood acute lymphoblastic leukemia: a matched-pair analysis. Berlin-Frankfurt-Münster Study Group.
- Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants.
- Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Medical Research Council Working Party on Childhood Leukaemia.
- Comparative genomic hybridization is a powerful tool, complementary to cytogenetics, to identify chromosomal abnormalities in childhood acute lymphoblastic leukaemia
- Extremely poor prognosis of pediatric acute lymphoblastic leukemia with translocation (9;22): updated experience.
- Molecular genetics of childhood cancer: implications for pathogenesis, diagnosis, and treatment.
- Detection of chromosome 11q23 involving translocations by pulsed field gel electrophoresis
- Allogeneic hematopoietic cell transplantation for patients with high-risk acute lymphoblastic leukemia in first or second complete remission using fractionated total-body irradiation and high-dose etoposide: a 15-year experience.
- Increased sensitivity of minimal residual disease detection by interphase FISH in acute lymphoblastic leukemia with hyperdiploidy
- Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X
- Allogeneic bone marrow transplant in pediatric patients with high-risk hematopoietic malignancies early in the course of their disease.
- Multiplex RT-PCR assay for the detection of major fusion transcripts in Taiwanese children with B-lineage acute lymphoblastic leukemia.
- Gender and treatment outcome in childhood lymphoblastic leukaemia: report from the MRC UKALL trials *
- Treatment of childhood acute lymphoblastic leukaemia: present issues and future prospects.
- Risk analysis in acute lymphoblastic leukaemia: problems and pitfalls.
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