Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products
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Summary
It is shown that MEF-2 is regulated by the myogenic regulatory factor myogenin and that mitogenic signals block this regulatory interaction, and it is suggested that growth factor signals suppress MEf-2 expression through repression of myogenicin expression or activity.
- Type
- article
- Published
- 1991-10-01
- Cited by
- 259
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1810995470
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34956614
Keywords
Myogenin, Myogenesis, Biology, Myocyte, Enhancer
References
- M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription
- Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.
- Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding.
- Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle.
- Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding
- Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.
- Myf‐6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.
- Isolation and characterization of the mouse cardiac myosin heavy chain genes.
- High level desmin expression depends on a muscle-specific enhancer.
- Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.
- Developmental regulation and tissue-specific expression of the human muscle creatine kinase gene.
- Two nuclear factors compete for the skeletal muscle actin promoter.
- Characterization of a promoter element required for transcription in myocardial cells.
- Structure of the gene encoding the muscle-specific subunit of human phosphoglycerate mutase.
- A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells
- Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a complex element governing myogenic induction of the avian cardiac alpha-actin promoter
- The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation
- Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene
- Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors
- Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells [published erratum appears in J Cell Biol 1990 Jun;110(6):2231]
Cited by
- Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C
- Coordinate positioning of MEF2 and myogenin binding sites.
- Molecular Cloning, Characterization, and Promoter Analysis of the Mouse Crp2/SmLim Gene
- Cibles moléculaires de la myostatine impliquées dans l'hypertrophie musculaire chez la souris et le bovin
- Rôle des facteurs de transcription SREBP-1 dans la fonction musculaire : implication des répresseurs transcriptionnels BHLHB2 et BHLHB3
- Regulatory Factors Involved in Cardiogenesis
- Molecular mechanisms of cardiac gene expression.
- Epigenetic regulation of skeletal muscle development and differentiation.
- The heart of the matter
- Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation
- Angiotensin and the Heart
- Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism
- MEF2B Is a Component of a Smooth Muscle-specific Complex That Binds an A/T-rich Element Important for Smooth Muscle Myosin Heavy Chain Gene Expression*
- Molecular Biology of Cardiac Development and Growth
- Pulsing response of the cardiac transcriptome
- A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression
- Myocyte-specific enhancer-binding factor (MEF-2) regulates alpha-cardiac myosin heavy chain gene expression in vitro and in vivo.
- Molecular genetics of succinate:quinone oxidoreductase in eukaryotes.
- Identification of myogenesis-dependent transcriptional enhancers in promoter region of mouse gamma-sarcoglycan gene.
- Anaylse der RyREF2-Bindungsstelle im Promotor des procinen RyR1 Gens und Characterisierung des procinen FHL1-Gens
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