HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.
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Summary
It is found that direct needle microinjection of activated Ras protein into primary neonatal rat ventricular cardiac myocytes does not induce DNA synthesis in these cells, and studies showing that activated Ras stimulates ANF promoter activity in transient transfection assays indicate a role for Ras in the hypertrophic effect of an alpha-adrenergic agonist.
- Type
- article
- Published
- 1993-01-25
- Cited by
- 216
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1810029706
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36750760
Keywords
HRAS, Cardiac hypertrophy, Muscle hypertrophy, Cell biology, Myocyte
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