Autophagy inhibits endothelial progenitor cells migration via the regulation of MMP2, MMP9 and uPA under normoxia condition.
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Summary
It is demonstrated that autophagy could regulate the EPCs migration through mTOR-P70 S6K pathway, and MMP2, MMP9 and uPA may also involve in the regulation mechanism.
- Type
- article
- Published
- 2015-10-23
- Cited by
- 32
- References
- 41
- OpenAlex
- https://openalex.org/W1805806684
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44329132
Keywords
Autophagy, MMP9, PI3K/AKT/mTOR pathway, ATG5, Cell biology
References
- Autophagy in Vascular Disease
- Endothelial progenitor cells accelerate the resolution of deep vein thrombosis.
- Autophagy: an emerging therapeutic target in vascular diseases
- Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon
- Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
- Autophagy protein 5 enhances the function of rat EPCs and promotes EPCs homing and thrombus recanalization via activating AKT.
- Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells.
- mTOR: a pharmacologic target for autophagy regulation.
- Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP‐9
- FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells.
- Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia
- MiR-150 enhances the motility of EPCs in vitro and promotes EPCs homing and thrombus resolving in vivo.
- SOX2 promotes the migration and invasion of laryngeal cancer cells by induction of MMP-2 via the PI3K/Akt/mTOR pathway.
- Transplanted Late Outgrowth Endothelial Progenitor Cells as Cell Therapy Product for Stroke
- Autophagy fights disease through cellular self-digestion
- Autophagy in vascular disease.
- Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition
- Endothelial Progenitor Cells: Current Development of Their Paracrine Factors in Cardiovascular Therapy
- mTOR SIGNALING IS A COMPONENT OF INTESTINAL REPAIR IN PIGLET ROTAVIRUS ENTERITIS: 69*
- Autophagy in Health and Disease: A Double-Edged Sword
Cited by
- Phosphoramide mustard induces autophagy markers and mTOR inhibition prevents follicle loss due to phosphoramide mustard exposure.
- Electroacupuncture preconditioning and postconditioning inhibit apoptosis and neuroinflammation induced by spinal cord ischemia reperfusion injury through enhancing autophagy in rats.
- Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway.
- Recombinant Thrombomodulin Exerts Anti-autophagic Action in Endothelial Cells and Provides Anti-atherosclerosis Effect in Apolipoprotein E Deficient Mice
- MMP9 is involved in HO-1-mediated upregulation of apical junctional complex in Caco-2 cells under oxygen-glucose deprivation.
- Naringin enhances endothelial progenitor cell (EPC) proliferation and tube formation capacity through the CXCL12/CXCR4/PI3K/Akt signaling pathway.
- Role of Autophagy in Endothelial Damage and Blood–Brain Barrier Disruption in Ischemic Stroke
- Nrf2 protects against diabetic dysfunction of endothelial progenitor cells via regulating cell senescence
- Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes
- The Role of Fibrinolytic Regulators in Vascular Dysfunction of Systemic Sclerosis
- Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells.
- Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP‐2 and MMP‐9 via H19/miR‐29b‐3p and AKT/mTOR/autophagy signaling pathways
- miR-19a promotes vascular smooth muscle cell proliferation, migration and invasion through regulation of Ras homolog family member B
- MiR‐205 promotes endothelial progenitor cell angiogenesis and deep vein thrombosis recanalization and resolution by targeting PTEN to regulate Akt/autophagy pathway and MMP2 expression
- LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway
- The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo
- Clarification of the Role of miR-9 in the Angiogenesis, Migration, and Autophagy of Endothelial Progenitor Cells Through RNA Sequence Analysis
- Toluene diisocyanate-induced inflammation and airway remodeling involves autophagy in human bronchial epithelial cells.
- Identification of Myocardial Infarction-Associated Genes Using Integrative microRNA-Gene Expression Network Analysis
- Intrinsic Mechanisms Regulating Neuronal Migration in the Postnatal Brain
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