MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications
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Summary
Their expression levels in CACs from T2DM with MACE suggest a shift from a proangiogenic to a proinflammatory profile, and Circulating miR-21-5p andmiR-126-3p emerge as dynamic biomarkers of systemic inflammatory/angIogenic status.
- Type
- article
- Published
- 2015-10-19
- Cited by
- 125
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1800547622
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13958267
Keywords
Medicine, Type 2 diabetes, Diabetes mellitus, microRNA, Angiogenesis
References
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- Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus
- Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications
- Atherosclerosis-Related Circulating miRNAs as Novel and Sensitive Predictors for Acute Myocardial Infarction
- Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction.
- Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma
- High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan
- Epigenetic signatures and vascular risk in type 2 diabetes: a clinical perspective.
- Telomere/telomerase system impairment in circulating angiogenic cells of geriatric patients with heart failure.
- Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
- Unacylated Ghrelin Induces Oxidative Stress Resistance in a Glucose Intolerance and Peripheral Artery Disease Mouse Model by Restoring Endothelial Cell miR-126 Expression
- miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes
- Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging.
- MicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins
- Serum metabolite signatures of type 2 diabetes mellitus complications.
- Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia/reperfusion Injury via PTEN/Akt Pathway
- microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism.
- Diagnostic Potential of Plasmatic MicroRNA Signatures in Stable and Unstable Angina
- miR-21: a star player in cardiac hypertrophy.
- Epigenetic mechanisms in diabetic complications and metabolic memory
Cited by
- Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume
- Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
- “Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes
- Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer.
- Circulating microRNAs as biomarkers for metabolic disease.
- Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA‐126‐Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full‐Thickness Skin Defects in a Diabetic Rat Model
- The role of microRNAs in prethrombotic status associated with coronary artery disease
- Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging
- Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
- MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke
- Circulating microRNAs: Promising Biomarkers Involved in Several Cancers and Other Diseases
- A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus
- Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
- Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
- T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
- Insights into the Diagnostic Potential of Extracellular Vesicles and Their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications
- Circulating miRNA‑21 is a promising biomarker for heart failure.
- MicroRNA and Diabetic Complications: A Clinical Perspective
- Upregulation of miR-126-3p promotes human saphenous vein endothelial cell proliferation in vitro and prevents vein graft neointimal formation ex vivo and in vivo
- Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects
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