Maladaptive striatal plasticity in L-DOPA-induced dyskinesia
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Summary
It is proposed that the core molecular alteration of striatal neurons in LID consists in an inability to turn down supersensitive signaling responses downstream of DA D1 receptors, which leads to abnormal cellular plasticity and high bioenergetic expenditure in the striatum.
- Type
- article
- Published
- 2010-01-01
- Cited by
- 222
- References
- 174
- Access
- Open access
- OpenAlex
- https://openalex.org/W1799696262
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26728764
Keywords
Neuroscience, Neurochemical, Striatum, Dyskinesia, Dopamine
References
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Cited by
- Glutamatergic pathways as a target for the treatment of dyskinesias in Parkinson's disease.
- Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link?
- Dazzled by the dominions of dopamine: clinical roles of D3, D2, and D1 receptors
- Animal models of l‐dopa‐induced dyskinesia in Parkinson's disease
- A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson's disease
- Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease.
- RGS proteins in experimental Parkinsonism and L-DOPA-induced dyskinesia
- Nicotine reduces established L-dopa-induced dyskinesias in a monkey model of Parkinson’s disease
- The β-lactam antibiotic ceftriaxone as a treatment for the symptoms of Parkinson’s disease and L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.
- Serotonergic modulation of receptor occupancy in rats treated with l‐DOPA after unilateral 6‐OHDA lesioning
- Presynaptic effects of L-DOPA and their possible role in dyskinesia
- Morphologic changes of dendritic spines of striatal neurons in the levodopa‐induced dyskinesia model
- Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease.
- Optimisation and mechanistic insights of dyskinesia in rodent models of Parkinson’s disease
- Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
- New approaches to therapy.
- Signal Transduction: Dopamine D1 receptor-induced signaling cascades in the striatum in Parkinson's disease
- Impact of L-DOPA treatment on regional cerebral blood flow and metabolism in the basal ganglia in a rat model of Parkinson's disease
- Aberrant Restoration of Spines and their Synapses in l-DOPA-Induced Dyskinesia: Involvement of Corticostriatal but Not Thalamostriatal Synapses
- The dopaminergic stabilizer pridopidine decreases expression of L-DOPA-induced locomotor sensitisation in the rat unilateral 6-OHDA model.
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