Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway
Explore this paper's citation graph
Summary
It is demonstrated that chitosan-conjugated AuNPs increase the deposition of calcium content and the expression of marker genes related to osteogenic differentiation in human adipose-derived mesenchymal stem cells at nontoxic concentrations and can be used as a reagent for promoting bone formation.
- Type
- article
- Published
- 2015-07-07
- Cited by
- 116
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1798499439
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4500990
Keywords
Mesenchymal stem cell, Wnt signaling pathway, Cell biology, Adipose tissue, Cellular differentiation
References
- Enhanced bone regeneration with a gold nanoparticle-hydrogel complex.
- Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.
- Osteoporosis as a risk factor for distal radial fractures: a case-control study.
- Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
- Chitosan enhances mineralization during osteoblast differentiation of human bone marrow‐derived mesenchymal stem cells, by upregulating the associated genes
- Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant.
- Wnt Signaling Behaves as a “Master Regulator” in the Osteogenic and Adipogenic Commitment of Human Amniotic Fluid Mesenchymal Stem Cells
- Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces
- Preparation and characterization of chitosan-carbon nanotube scaffolds for bone tissue engineering.
- Effect of gold/Fe 3 O 4 nanoparticles on biocompatibility and neural differentiation of rat olfactory bulb neural stem cells
- Electrically conductive gold-coated collagen nanofibers for placental-derived mesenchymal stem cells enhanced differentiation and proliferation.
- The Wnt/beta-catenin signaling pathway as a target in drug discovery.
- β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts*
- Wnt/β-catenin signaling enhances osteoblastogenic differentiation from human periodontal ligament fibroblasts
- Influence of nanomaterials on stem cell differentiation: designing an appropriate nanobiointerface
- Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal.
- Gold nanoparticles stimulate differentiation and mineralization of primary osteoblasts through the ERK/MAPK signaling pathway.
- Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway.
- The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review
- Human and animal mesenchymal progenitor cells from bone marrow: Identification of serum for optimal selection and proliferation
Cited by
- Gold nanoparticle size and shape influence on osteogenesis of mesenchymal stem cells.
- Gold Nanoparticles Promote Proliferation of Human Periodontal Ligament Stem Cells and Have Limited Effects on Cells Differentiation
- Gold nanoparticles with surface-anchored chiral poly(acryloyl-L(D)-valine) induce differential response on mesenchymal stem cell osteogenesis
- An update on the Application of Nanotechnology in Bone Tissue Engineering
- One low-dose exposure of gold nanoparticles induces long-term changes in human cells
- Insight into the interactions between nanoparticles and cells.
- Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt/β-catenin signaling
- Sub-10 nm gold nanoparticles promote adipogenesis and inhibit osteogenesis of mesenchymal stem cells.
- Micro-Computed Tomography Detection of Gold Nanoparticle-Labelled Mesenchymal Stem Cells in the Rat Subretinal Layer
- Size-dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells
- Nanoparticles for the treatment of osteoporosis
- Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells.
- The negative effect of silica nanoparticles on adipogenic differentiation of human mesenchymal stem cells.
- Effects of Metal Micro and Nano-Particles on hASCs: An In Vitro Model
- Gold nanoparticles in injectable calcium phosphate cement enhance osteogenic differentiation of human dental pulp stem cells
- Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering.
- Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms
- Gold Nanoparticles Inducing Osteogenic Differentiation of Stem Cells: A Review
- Mesenchymal stem cells from human adipose tissue and bone repair: a literature review
- Cytotoxic Effect of Chitosan-Gold Nanoparticles on Two Cell Lines in Culture
Related papers
- Differential WNT gene expression in various subtypes of acute lymphoblastic leukemia.
- Wnt Versus Wnt
- 943 Temporal-spatial activation of Wnt-signaling within Type1 / Type 2 immunity during wound healing
- [The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application].
- Advancement of Wnt signal pathway and the target of breast cancer
- New insights into the regulation of Axin function in canonical Wnt signaling pathway
- Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
- Nkd1 Functions as a Passive Antagonist of Wnt Signaling
- [Adipogenic potential of bone marrow mesenchymal stem cells derived from ovariectomized rats].