Crystal structure and assembly of a eukaryotic small heat shock protein
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Summary
The 2.7 Å structure of wheat HSP16.9, a member of the small heat shock proteins (sHSPs), indicates how its α-crystallin domain and flanking extensions assemble into a dodecameric double disk, and provides a model by which members of the sHSP protein family bind unfolded substrates.
- Type
- article
- Published
- 2001-12-01
- Cited by
- 737
- References
- 40
- OpenAlex
- https://openalex.org/W1797775581
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:618916
Keywords
Oligomer, Protein folding, Biophysics, Chemistry, Chaperone (clinical)
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Cited by
- Multi-subunit assembly of the Pyrococcus furiosus small heat shock protein is essential for cellular protection at high temperature
- Characterization of a unique genomic clone located 5′ upstream of the Oshsp16.9B gene on chromosome 1 in rice (Oryza sativa L. cv Tainung No. 67)
- Tsp36, a tapeworm small heat‐shock protein with a duplicated α‐crystallin domain, forms dimers and tetramers with good chaperone‐like activity
- Interaction of a Small Heat Shock Protein of the Fission Yeast, Schizosaccharomyces pombe, with a Denatured Protein at Elevated Temperature*
- Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain.
- Characterization of a sHsp of Schizosaccharomyces pombe, SpHsp15.8, and the implication of its functional mechanism by comparison with another sHsp, SpHsp16.0
- Overexpression of small heat shock protein 21 protects the Chinese oak silkworm Antheraea pernyi against thermal stress.
- Adaptive evolution of duplicated hsp17 genes in wild barley from microclimatically divergent sites of Israel.
- FUNCTIONAL SEQUENCES in HUMAN alphaB CRYSTALLIN
- Fusion Molecules of Heat Shock Protein HSPX with Other Antigens of Mycobacterium tuberculosis Show High Potential in Serodiagnosis of Tuberculosis
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- Biochemical and biophysical characterization of small heat shock proteins from sugarcane. Involvement of a specific region located at the N-terminus with substrate specificity.
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- The role of Hsp20 in Alzheimer's disease
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- THE ROLE OF CYTOPLASMIC CHAPERONES IN THE BIOGENESIS, MATURATION, AND DEGRADATION OF CYTOPLASMIC AND INTEGRAL MEMBRANE PROTEINS
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