Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7.
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Summary
Both t-MDS and t-ANLL are late complications of cytotoxic therapies that have distinctive clinical and histologic features and are associated with characteristic aberrations of chromosomes no. 5 and 7, and it seems likely that these two chromosomes contain genes involved in the pathogenesis of these hematopoietic neoplasms.
- Type
- article
- Published
- 1986-03-01
- Cited by
- 667
- References
- 31
- OpenAlex
- https://openalex.org/W1796305773
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6722240
Keywords
Radiation therapy, Myelodysplastic syndromes, Medicine, Chemotherapy, Bone marrow
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Cited by
- The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation.
- Cytogenetic studies of long-term survivors of childhood acute lymphoblastic leukemia: a follow-up report.
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