Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
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Summary
The role played by COX is highlighted in disturbing the balance between MMPs and TIMPs in prostate cancer cells, and it points to the potential use of COX inibitors, especially COX-2 selective inhibitors, in the prevention and therapy of prostate cancer invasion.
- Type
- article
- Published
- 2000-08-15
- Cited by
- 321
- References
- 53
- OpenAlex
- https://openalex.org/W1794877746
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12953162
Keywords
Matrigel, Prostaglandin, Phospholipase A2, Cell culture, Chemistry
References
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- Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.
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- Arachidonic Acid in Cell Signaling
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- Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention.
- Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
- Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.
- Effects of fatty acids on invasion through reconstituted basement membrane ('Matrigel') by a human breast cancer cell line.
Cited by
- Analyse und Modulation des Tumormetabolismus in humanen Tumorzelllinien und Tumorgeweben
- Vitreous induces components of the prostaglandin E2 pathway in human retinal pigment epithelial cells.
- Interleukin-1β stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes
- Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance.
- Arachidonic acid-induced gene expression in colon cancer cells.
- Cyclooxygenase-2 Inhibition Prevents Migration of Colorectal Cancer Cells to Extracellular Matrix by Down-Regulation of Matrix Metalloproteinase-2 Expression
- Androgen receptor is a tumor suppressor and proliferator in prostate cancer
- Pomegranate and Its Components as Alternative Treatment for Prostate Cancer
- Non-steroidal anti-inflammatory drugs and cancer, with an especial focus on esophageal cancer.
- The effect of conjugated linoleic acid on the proliferation, migration and invasion of a murine mammary cancer cell line
- Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer
- Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats
- COX-2 Specific Inhibitor, NS-398, Increases Macrophage Migration Inhibitory Factor Expression and Induces Neuroendocrine Differentiation in C4-2b Prostate Cancer Cells
- Assessment of oxidants in mitogen-activated protein kinase activation.
- Mechanisms of immune evasion by gliomas.
- Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer.
- Rol de la ciclooxigenasa-2 en la progresión de tumores de pulmón y mama
- Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis.
- 選択的COX-2阻害はMMP-9の発現低下を介して口腔扁平上皮癌細胞の浸潤能を抑制する
- Untersuchung der Expression von Cyclooxygenase-2, VEGF und der Gefäßdichte im Nierenzellkarzinom
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