Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.

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Summary

The role played by COX is highlighted in disturbing the balance between MMPs and TIMPs in prostate cancer cells, and it points to the potential use of COX inibitors, especially COX-2 selective inhibitors, in the prevention and therapy of prostate cancer invasion.

Type
article
Published
2000-08-15
Cited by
321
References
53

Keywords

Matrigel, Prostaglandin, Phospholipase A2, Cell culture, Chemistry

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