The linkage between β1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of β1 integrin in normal and cancerous human breast cells
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- Type
- article
- Published
- 2001-11-08
- Cited by
- 23
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1793988582
Keywords
Tyrosine phosphorylation, Biology, Protein tyrosine phosphatase, Integrin, Phosphorylation
References
- Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system.
- Isolation and characterization of temperature-sensitive and thermostable mutants of the human receptor-like protein tyrosine phosphatase LAR.
- A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
- KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
- Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.
- Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain.
- Integrin transmembrane signaling and cytoskeletal control.
- Interaction of iodinated vinculin, metavinculin and alpha-actinin with cytoskeletal proteins.
- The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle.
- An interaction between vinculin and talin
- Kinetic determination of talin-actin binding.
- Loss of density-dependent growth inhibition and dissociation of alpha-catenin from E-cadherin.
- Assignment of the gene encoding the beta‐subunit of the human fibronectin receptor (β‐FNR) to chromosome 10p11.2
- Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.
- Tyrosine Phosphorylation of the β3 Cytoplasmic Domain Mediates Integrin-Cytoskeletal Interactions*
- Specific interaction of vinculin with alpha-actinin.
- Detection of high molecular weight vinculin binding proteins in muscle and nonmuscle tissues with an electroblot-overlay technique.
- Direct interactions between talin and actin.
- Calcium's Role in Mechanotransduction during Muscle Development
- Induction of tyrosine phosphorylation and association of β-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence
Cited by
- Disruption of Focal Adhesions by Integrin Cytoplasmic Domain-associated Protein-1α*
- Regulation of protein phosphatase 2A‐mediated recruitment of IQGAP1 to β1 integrin by EGF through activation of Ca2+/calmodulin‐dependent protein kinase II
- Mitotic dissociation of IQGAP1 from Rac-bound beta1-integrin is mediated by protein phosphatase 2A.
- Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src.
- Requirement of protein phosphatase 2A for recruitment of IQGAP1 to Rac‐bound β1 integrin
- Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts.
- Proteomics Analysis Identifies Molecular Targets Related to Diabetes Mellitus-associated Bladder Dysfunction *S
- Reorganization of cytoskeletal proteins of mouse oocytes mediated by integrins
- Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy
- Acute Lung Injury Following Inhalation Exposure to Nerve Agent VX in Guinea Pigs
- Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells.
- Down-Regulation of 3-Phosphoinositide–Dependent Protein Kinase-1 Levels Inhibits Migration and Experimental Metastasis of Human Breast Cancer Cells
- Targeting Signal Transduction Pathways to Eliminate Chemotherapeutic Drug Resistance and Cancer Stem Cells
- Reduced cell adhesion during mitosis by threonine phosphorylation of β1 integrin
- CaMK-II Promotes Focal Adhesion Turnover and Cell Motility by Inducing Tyrosine Dephosphorylation of FAK and Paxillin
- PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling
- Investigating pathways in tumour cell migration and invasion in response to novel isoquinolinone compounds
- NCAM affects directional lamellipodia formation of BMSCs via β1 integrin signal-mediated cofilin activity
- Functional importance of PP2A regulatory subunit loss in breast cancer
- PPM1F controls integrin activity via a conserved phospho-switch
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