A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice.
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Summary
A critical role for CCR5 is found in the induction of T-cell migration to tumor sites after IL-12 treatment and anti-CCR5 antibody was found to inhibit T- cell migration in the lymphoid cell migration assay.
- Type
- article
- Published
- 2002-07-01
- Cited by
- 54
- References
- 67
- OpenAlex
- https://openalex.org/W1793524329
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6308690
Keywords
Chemokine, CCL5, Cancer research, Immunotherapy, T cell
References
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- Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease.
- Extension of Recombinant Human RANTES by the Retention of the Initiating Methionine Produces a Potent Antagonist (*)
Cited by
- Characterization of natural autoantibodies: A case for functional significance
- Caractérisation moléculaire et fonctionnelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs pulmonaires humaines
- Telomerase mRNA-Transfected Dendritic Cells Stimulate Antigen-Specific CD8+ and CD4+ T Cell Responses in Patients with Metastatic Prostate Cancer 1
- Gene Therapy to Manipulate Effector T Cell Trafficking to Tumors for Immunotherapy 1
- Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8+ T Cells and Dependence on IL-4 Production1
- CD8+CD103+ Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients
- IL-12 Regulates an Endothelial Cell-Lymphocyte Network: Effect on Metalloproteinase-9 Production1
- Interleukin 12 Induces T-Cell Recruitment Into the Atherosclerotic Plaque
- Desensitization of T lymphocyte function by CXCR3 ligands in human hepatocellular carcinoma.
- CCL5-28, CCL5-403, and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinoma
- Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model.
- Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor.
- Reduced Expression of Chemokine Receptors on Peripheral Blood Lymphocytes in Patients with Hepatocellular Carcinoma
- CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells.
- Antitumor mechanism of intratumoral injection with IL-12-expressing adenoviral vector against IL-12-unresponsive tumor.
- Neem Leaf Glycoprotein Activates CD8+ T Cells to Promote Therapeutic Anti-Tumor Immunity Inhibiting the Growth of Mouse Sarcoma
- Regulation of cytotoxic T-Lymphocyte trafficking to tumors by chemoattractants: implications for immunotherapy
- Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model.
- Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS
- Rituximab induces different but overlapping sets of genes in human B-lymphoma cell lines
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