Cytosolic‐free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia
Explore this paper's citation graph
Summary
Together, these results strongly suggest that a sustained increase in cytosolic Ca2+ concentration plays an important role in killing of hepatoma cells by chemical anoxia.
- Type
- article
- Published
- 1989-01-01
- Cited by
- 98
- References
- 36
- OpenAlex
- https://openalex.org/W1793488575
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15517716
Keywords
Cytosol, Intracellular, Glutathione, Chemistry, Biochemistry
References
- Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.
- Role of thiols in protection against biological reactive intermediates.
- Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle.
- Studies on the calcium dependence of human NK cell killing.
- Chemical modification of actin. Acceleration of polymerization and reduction of network formation by reaction with N-ethylmaleimide, (iodoacetamido)tetramethylrhodamine, or 7-chloro-4-nitro-2,1,3-benzoxadiazole.
- Actin-binding proteins—regulators of cell architecture and motility
- Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells
- Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin.
- The effects of cyanide and its interactions with norepinephrine on isolated aorta strips from the rabbit, dog, and ferret.
- The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells.
- Intracellular free calcium rise triggers nuclear envelope breakdown in the sea urchin embryo
- The role of calcium in cell injury and repair: a hypothesis.
- Assessment of the role of calcium ion in halocarbon hepatotoxicity.
- Alteration of cytosolic calcium levels in PC12 cells by potassium cyanide.
- Mitochondrial calcium transport
- The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
- Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes
- The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non‐lysosomal proteolytic system
- Altered thiol and calcium homeostasis in oxidative hepatocellular injury
- Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.
Cited by
- Ca(2+)-dependent and independent mitochondrial damage in hepatocellular injury.
- Ischemic effects on the structure and function of the plasma membrane.
- Mechanisms of hypoxic cell injury. Summary of the symposium presented at the 1990 annual meeting of the Society of Toxicology.
- ROLE OF INTRACELLULAR THlOL STATIUS AND CALCIUM HOMEOSTASIS IN MYOCARDIAL CELL INJURY
- Chemical Hypoxia-Induced Cell Death in Human Glioma Cells: Role of Reactive Oxygen Species, ATP Depletion, Mitochondrial Damage and Ca2+
- A role for Na+‐dependent Ca2+ extrusion in protection against neuronal excitotoxicity
- Ca2+ and Cell Death a
- Role of calcium in toxic and programmed cell death.
- Intracellular Ca2+ thresholds that determine survival or death of energy-deprived cells.
- Clostridium difficile toxin A elicits Ca(2+)-independent cytotoxic effects in cultured normal rat intestinal crypt cells
- Mitochondrial dysfunction induced by Bisphenol A is a factor of its hepatotoxicity in rats
- Verapamil treatment of canine hemorrhagic shock.
- Cell Death Mechanisms and the Immune System
- Ascorbic acid requirement for optimal flexor tendon repair in vitro
- Necrotic volume increase and the early physiology of necrosis.
- Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.
- Oxidative Stress and Cytoskeletal Alterations a
- Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo.
- Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.
- Paradoxical potentiation by low extracellular Ca2+ of acute chemical anoxic neuronal injury in cerebellar granule cell culture.
Related papers
- Comparison of the delivery of reduced glutathione into P388D1 cells by reduced glutathione and its mono- and diethyl ester derivatives.
- Synthesis and transport of glutathione by cultured human retinal pigment epithelial cells.
- Different responses of cytosolic and mitochondrial glutathione in rat livers after ethylene oxide exposure.
- Effect of TEGDMA on the intracellular glutathione concentration of human gingival fibroblasts.
- The pathway for refilling intracellular Ca2+ stores passes through the cytosol in human leukaemia cells
- Effect of nanoparticle surface charge at the plasma membrane and beyond
- Damage of E.coli cell membrane and intracellular enzymic activity induced by pulsed light irradiation