Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior.
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Summary
The ability to co-express vimentin and keratins confers a selective advantage to breast cancer cells in their interpretation of signaling cues from the extracellular matrix; however the addition of vimentsin intermediate filaments alone is not sufficient to confer the metastatic phenotype.
- Type
- article
- Published
- 1997-02-01
- Cited by
- 287
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1792974413
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42636793
Keywords
Vimentin, Intermediate filament, Keratin, Biology, Laminin
References
- Mammary epithelial cells, extracellular matrix, and gene expression.
- Vimentin is preferentially expressed in high-grade ductal and medullary, but not in lobular breast carcinomas.
- Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction.
- A negative regulatory factor is missing in a human metastatic breast cancer cell line.
- Signaling site of laminin with mitogenic activity.
- Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.
- Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma cells augments motility.
- Coexpression of cytokeratins characteristic for myoepithelial and luminal cell lineages in rat 13762NF mammary adenocarcinoma tumors and their spontaneous metastases.
- Intermediate filament protein synthesis in preimplantation murine embryos.
- Intermediate filament dynamics.
- Intermediate filament molecular biology.
- Integrins as mechanochemical transducers.
- Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.
- Vimentin—a new prognostic parameter in breast carcinoma?
- Inside-out integrin signalling.
- The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.
- Intermediate filaments: cell-type-specific markers in differentiation and pathology.
- Expression of the cytokeratin endo A gene during early mouse embryogenesis.
- The internal affairs of an integrin.
- Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.
Cited by
- Tumorigenicity of the mixed spindle-epithelioid SP6.5 and epithelioid TP17 uveal melanoma cell lines is differentially related to alpha5beta1 integrin expression.
- Stress models for the study of intermediate filament function.
- Use of two‐dimensional gel electrophoresis in predictive toxicology: Identification of potential early protein biomarkers in chemically induced hepatocarcinogenesis
- Proteomic Characterization of the Conditioned Media Produced by the Visceral Endoderm-Like Cell Lines HepG2 and END2: Toward a Defined Medium for the Osteogenic/Chondrogenic Differentiation of Embryonic Stem Cells
- Histological, Immunohistological, and Ultrastructural Description of Vasculogenic Mimicry in Canine Mammary Cancer
- Vimentin on the move: new developments in cell migration
- Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma
- Modulation of the malignant phenotype of human prostate cancer cells by N-(4-hydroxyphenyl)retinamide (4-HPR)
- The detection of potential drug resistance markers using proteomic technologies
- Expounding Maspin and IRF6: identification and characterization of a novel serpin partnership
- Circulating nucleic acids in plasma and serum (CNAPS) and its relation to stem cells and cancer metastasis: state of the issue.
- Identification of proteins associated with cancerous and invasive phenotypes of breast and melanoma cells using proteomic approaches
- Transcriptional alterations during mammary tumor progression in mice and humans
- 1,25-dihydroxyvitamin D alters lipid metabolism and epithelial-to-mesenchymal transition in metastatic epithelial breast cancer cells
- Cell Motility in Cancer Invasion and Metastasis
- Neoplasias mamárias de cadelas: expressão gênica e proteica da via Wnt/b-catenina, sua associação com a transição epitélio-mesênquima e prognóstico
- Neuronal and metastatic cancer cells: Unlike brothers.
- Temporal Control of Transforming Growth Factor (TGF) - Betal Expression on Mammary Cell Multistep Transformation
- Vimentin and Epithelial-Mesenchymal Transition in Human Breast Cancer – Observations in vitro and in vivo
- HUMAN ENDOGENOUS RETROVIRUS K AS A NOVEL TUMOR-ASSOCIATED ANTIGEN FOR DEVELOPMENT OF AN OVARIAN CANCER VACCINE
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