Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord.
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Summary
Observations indicate that opb embryos exhibit defects in the specification of cells along the dorsoventral axis of the developing spinal cord, similar to known mouse mutants exhibiting similar defects.
- Type
- article
- Published
- 1994-11-01
- Cited by
- 101
- References
- 43
- OpenAlex
- https://openalex.org/W1792160393
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21973423
Keywords
Biology, Neural tube, Mutant, Spinal cord, Gene
References
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- The role of transcriptional repression in Shh signalling and patterning of the ventral neural tube
- Developmental roles and clinical significance of hedgehog signaling.
- Modeling neural tube defects in the mouse.
- Rab23: What Exactly Does it Traffic?
- Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
- Toll-mediated cellular immune response in Drosophila melanogaster
- Psx, a novel murine homeobox gene expressed in placenta.
- Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects.
- A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment
- The Immunohistochemical Profile of the Myelomeningocele Placode: Is the Placode Normal?
- Developmental biology: Vesicles and the spinal cord
- BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.
- Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene.
- SNPs in the CpG island of NAP1L2: a possible link between DNA methylation and neural tube defects?
- The genetic basis of mammalian neurulation
- Genetic landmarks for defects in mouse neural tube closure.
- Emerging roles for Rab family GTPases in human cancer.
- Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects.
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