Angiostatic treatment of neuroblastoma.
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Summary
The effects of treatment with the angiostatic agent TNP-470 in an experimental model results in a significant reduction of the tumour growth rate, reduced microvascular counts and a reduced fraction of viable tumour cells compared to controls.
- Type
- review
- Published
- 1997-01-01
- Cited by
- 41
- References
- 77
- Access
- Open access
- OpenAlex
- https://openalex.org/W1789842795
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22929801
Keywords
Angiogenesis, Neuroblastoma, Fumagillin, Medicine, Endocrinology
References
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- Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.
- The athymic nude rat. I. Morphology of lymphoid and endocrine organs.
- The Pharmacokinetics of TNP‐470, a New Angiogenesis Inhibitor
- In vivo spontaneous neuronal to neuroendocrine lineage conversion in a subset of neuroblastomas.
- Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature.
- Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
- A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage.
- An alpha-D-galactosyl-binding lectin from Bandeiraea simplicifolia seeds. Isolation by affinity chromatography and characterization.
- IGF2 expression is a marker for paraganglionic/SIF cell differentiation in neuroblastoma.
- Combined effects of angiostatin and ionizing radiation in antitumour therapy
- Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.
- Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma.
- Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool.
- Principles and Practice of Pediatric Oncology
- Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
- Inhibition of angiogenesis in vivo by interleukin 12.
- Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients.
- Tumor angiogenesis: therapeutic implications.
Cited by
- A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells
- In vitro evaluering van 2-metoksie-estradiol-bissulfamaat op selgroei, morfologie, selsiklus en die moontlike induksie van tipe seldood in ’n esofagus karsinoom senyn
- Antitumor Effect of TNP-470 is not Associated to Decrease of Angiogenesis in an Experimental Malignant Neuroectodermic Tumor
- Antitumor Activities of 2-Methoxyestradiol on Cervical and Endometrial Cancers In Vitro and In Vivo
- Angiogenesis in neuroblastoma: relationship to survival and other prognostic factors in a cohort of neuroblastoma patients.
- 2-Methoxyestradiol--biology and mechanism of action.
- 2‐Methoxyestradiol modulates β‐catenin in prostate cancer cells: A possible mediator of 2‐methoxyestradiol‐induced inhibition of cell growth
- Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells
- Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors
- Antiproliferative activity and toxicity of 2-methoxyestradiol in cervical cancer xenograft mice
- 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis
- Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma
- Synthesis, cytotoxic effects and tubulin polymerization inhibition of 1,4-disubstituted 1,2,3-triazole analogs of 2-methoxyestradiol.
- The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
- Stimulation of Suicidal Erythrocyte Death by Fumagillin
- Dipeptidyl Peptidases as Survival Factors in Ewing Sarcoma Family of Tumors
- Expression of vascular endothelial growth factor and its receptor Flk-1 in human neuroblastoma using in situ hybridization.
- Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2-methoxyestradiol.
- Inhibition of angiogenesis at endothelial cell level
- Neuropeptide Y and its Y2 Receptor – Potential Targets in Neuroblastoma Therapy
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