Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells
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Summary
A model for the functional hemizygosity of mammalian cell lines, which is based on the inactivation of genes by de novo hypermethylation, is presented and it is proposed that the xrs strains are mutants derived from an active wild-type gene.
- Type
- article
- Published
- 1986-08-01
- Cited by
- 113
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1789577188
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22110689
Keywords
Biology, Chinese hamster ovary cell, Gene, Mutant, DNA
References
- Electrophoretic shift mutants in Chinese hamster ovary cells: evidence for genetic diploidy.
- Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro.
- DNA methylation and gene activity.
- Specific methylation pattern at the 3′ end of the human housekeeping gene for glucose 6‐phosphate dehydrogenase.
- Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA.
- DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells
- Induction and analysis of gene mutations in cultured mammalian somatic cells.
- DNA methylation in eukaryotic cells.
- 5-methylcytosine, gene regulation, and cancer.
- Linkage of the MBG locus to another functionally hemizygous gene locus (IDH2) on chromosome Z3 in Chinese hamster ovary cells
- Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: implications for mechanisms regulating metallothionein gene expression
- Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.
- Genetic analysis of X-ray-sensitive mutants of the CHO cell line.
- DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells.
- Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation.
- 5-Azacytidine-induced reactivation of a herpes simplex thymidine kinase gene.
- Provisional assignment of TPI, GPI, and PEPD to Chinese hamster autosomes 8 and 9: a cytogenetic basis for functional haploidy of an autosomal linkage group in CHO cells.
- Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells.
- 5-azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line.
- Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection.
Cited by
- Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection
- A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine.
- Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants
- Histone-modifier genes regulate morphogenesis of "Candida albicans"
- Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.
- The role of RAD51-like genes in the repair of DNA damage in mammalian cells
- Heritable high frequency modulation of antigen expression in neoplastic cells exposed to 5-aza-2'-deoxycytidine or hydroxyurea: analysis and implications.
- Effekt des Knockdowns von Rad51 mittels RNA-Interferenz auf die Homologie-vermittelte DNA-Reparatur
- Developmental characterization and chromosomal mapping of the 5-azacytidine-sensitive fluF locus of Aspergillus nidulans
- Molecular and biochemical characterization of xrs mutants defective in Ku80
- A DNA end-binding factor involved in double-strand break repair and V(D)J recombination
- Genomic imprinting and allelic exclusion.
- DNA methylation in xeroderma pigmentosum.
- Interaction effects of 5-azacytidine with topoisomerase II inhibitors on CHO cells, as detected by cytogenetic analysis.
- Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.
- Altered metaphase chromosome structure in xrs-5 cells is not related to its radiation sensitivity or defective DNA break rejoining.
- CpG methylation of viral DNA in EBV‐associated tumours
- DNA methylation and epigenetic inheritance.
- Segregation analysis of rare autosomal folate sensitive fragile sites.
- Repair of DNA single-strand and double-strand breaks in the Chinese hamster xrs 5 mutant cell line as determined by DNA unwinding.
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