Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons.
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Summary
The activation of dendritic voltage-gated Ca(2+) channels, by large-amplitude backpropagating spikes, provides a prolonged inward current that is capable of generating an ADP and burst of multiple action potentials in the soma of CA1 pyramidal neurons.
- Type
- article
- Published
- 1999-10-01
- Cited by
- 309
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1789081904
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9181135
Keywords
Afterhyperpolarization, Bursting, Apical dendrite, Dendritic spike, Soma
References
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- Arachidonic Acid Inhibits Transient Potassium Currents and Broadens Action Potentials during Electrographic Seizures in Hippocampal Pyramidal and Inhibitory Interneurons
- Dendritic Spikes Are Enhanced by Cooperative Network Activity in the Intact Hippocampus
- Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes
- Postsynaptic Complex Spike Bursting Enables the Induction of LTP by Theta Frequency Synaptic Stimulation
- Characterization of single voltage‐gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons.
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- Two-stage model of memory trace formation: a role for "noisy" brain states.
- Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivo.
- Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel.
- Dendritic integration in mammalian neurons, a century after Cajal.
Cited by
- Electrophysiological and morphological diversity of neurons from the rat subicular complex in vitro
- Integration Time in a Subset of Spinal Lamina I Neurons Is Lengthened by Sodium and Calcium Currents Acting Synergistically to Prolong Subthreshold Depolarization
- Dynamical basis of irregular spiking in NMDA-driven prefrontal cortex neurons.
- An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus.
- Neural Coding With Bursts—Current State and Future Perspectives
- Firing and intrinsic properties of antennal lobe neurons in the Noctuid moth Agrotis ipsilon
- Cav3.1 T-type calcium channel modulates the epileptogenicity of hippocampal seizures in the kainic acid-induced temporal lobe epilepsy model.
- [Cellular mechanisms regulating neuronal excitability: functional implications and in epilepsy].
- Photogenetic Retinal Prosthesis
- Modulation of afterpotentials and firing pattern in guinea pig CA3 neurones by group I metabotropic glutamate receptors
- Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway
- Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons
- Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting
- Dendritic D‐type potassium currents inhibit the spike afterdepolarization in rat hippocampal CA1 pyramidal neurons
- Activity‐dependent downregulation of D‐type K+ channel subunit Kv1.2 in rat hippocampal CA3 pyramidal neurons
- Recruitment of apical dendritic T‐type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis
- A transitional period of Ca2+‐dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells
- Trace Fear Conditioning Differentially Modulates Intrinsic Excitability of Medial Prefrontal Cortex–Basolateral Complex of Amygdala Projection Neurons in Infralimbic and Prelimbic Cortices
- Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
- Kurtoxin, A Gating Modifier of Neuronal High- and Low-Threshold Ca Channels
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