Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
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Summary
A sensitive method for the measurement of antipyrine metabolites formed in the in vitro incubations and applied it to determine the P450s participating in the formation of each metabolite in human liver microsomes, finding the predominant form involved in 3-hydroxymethylantipyrine formation was found to be 1A2, although 2C9 and 2E1 seemed to participate to a lesser extent.
- Type
- article
- Published
- 1996-04-01
- Cited by
- 72
- References
- 0
- OpenAlex
- https://openalex.org/W1788624086
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33050074
Keywords
Metabolite, Microsome, Cytochrome P450, Chemistry, Biochemistry
References
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Cited by
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- The Interaction of Antiparasitic Drugs with the Drug-metabolising Cytochrome P450s (CYPs) and Characterisation of a CYP Variant Unique to African Populations.
- Relationships among liver and kidney volumes, lean body mass and drug clearance.
- Ontogeny and Pharmacogenetics: Determinants of Age-Associated Differences in Drug Clearance During Human Development
- Direct nuclear magnetic resonance spectroscopic analysis of (13)C-labeled antipyrine metabolites in human urine.
- Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: preliminary evidence for CYP3A isoforms in pigs.
- Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.
- Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.
- Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation.
- Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement.
- The Effect of Aging on the Relationship between the Cytochrome P450 2C19 Genotype and Omeprazole Pharmacokinetics
- Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test
- Ontogeny of drug metabolizing enzymes in the neonate.
- Effect of tacrine hydrochloride on hepatic drug metabolism
- Using Improved Serial Blood Sampling Method of Mice to Study Pharmacokinetics and Drug-Drug Interaction.
- Immunosuppression in pediatric liver transplantation: Are little people different?
- A comparison of the effect of five phenothiazines on hepatic CYP isoenzymes in rats.
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