WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis Through an Actin Comet Tail Mechanism
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Summary
It is found that WHAMM forms puncta that colocalize and comigrate with the autophagy markers LC3, DFCP1 and p62 through a WHAMM-dependent actin-comet tail mechanism, revealing a link between Arp2/3 complex-dependent actin assembly and autophagy.
- Type
- article
- Published
- 2015-06-18
- Cited by
- 117
- References
- 18
- Access
- Open access
- OpenAlex
- https://openalex.org/W1779577685
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:92793
Keywords
Biology, Cell biology, Mechanism (biology), Biogenesis, Actin
References
- Monitoring autophagic degradation of p62/SQSTM1.
- Species, extinct before we know them?
- Eaten alive: a history of macroautophagy
- Structural insights into de novo actin polymerization
- The autophagosome: origins unknown, biogenesis complex
- JMY is involved in anterograde vesicle trafficking from the trans-Golgi network.
- WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond.
- p53-cofactor JMY is a Multifunctional Actin Nucleation Factor
- 3D tomography reveals connections between the phagophore and endoplasmic reticulum
- The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy
- Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis
- WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport
- Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling
- Characterization of two classes of small molecule inhibitors of Arp2/3 complex
- Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
- A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
- A novel cofactor for p300 that regulates the p53 response.
- A kinematic description of the trajectories of Listeria monocytogenes propelled by actin comet tails
Cited by
- CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane
- Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation
- To deliver or to degrade – an interplay of the ubiquitin–proteasome system, autophagy and vesicular transport in plants
- Digesting the Expanding Mechanisms of Autophagy.
- Regulation of actin nucleation and autophagosome formation
- Myosins, Actin and Autophagy
- Profilin connects actin assembly with microtubule dynamics
- Arabidopsis NAP1 Regulates the Formation of Autophagosomes.
- Single Cell Transcriptomics, Mega-Phylogeny, and the Genetic Basis of Morphological Innovations in Rhizaria
- Autophagy: Press and Push for Destruction
- Role of actin in shaping autophagosomes
- WASP family proteins, more than Arp2/3 activators
- Signalling Pathways Controlling Cellular Actin Organization.
- Understanding the mechanisms underlying force transmission during epithelial cell division
- Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds
- Structural Insights of WHAMM's Interaction with Microtubules by Cryo-EM.
- The Cytoskeleton-Autophagy Connection
- Cellular functions of WASP family proteins at a glance
- An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex–driven autophagosomal remodeling pathway
- Connecting membranes to the actin cytoskeleton.
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