Cellular consequences of thrombin-receptor activation.
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Summary
While most studies of thrombin have concentrated on its action on cells involved in blood clotting and wound healing, it is now becoming apparent that it can modulate the growth and differentiation status of cells of neuronal origin.
- Type
- review
- Published
- 1996-01-15
- Cited by
- 328
- References
- 234
- Access
- Open access
- OpenAlex
- https://openalex.org/W1774746154
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39623038
Keywords
Citation, Icon, Library science, Download, Computer science
References
- Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets
- Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
- Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary culture
- Thrombin active site regions required for fibroblast receptor binding and initiation of cell division.
- Monocyte chemotaxis: stimulation by specific exosite region in thrombin.
- Small GTP-binding proteins and the regulation of the actin cytoskeleton.
- Interferon-activated signal transduction to the nucleus.
- Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.
- cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
- A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-beta 1.
- Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets.
- Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.
- Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.
- Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors.
- Synthesis and secretion of nerve growth factor by mouse astroglial cells in culture.
- Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes.
- Neuron-glia interrelations.
- Pertussis toxin inhibits thrombin‐induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.
- Inhibition of protease activity can lead to neurite extension in neuroblastoma cells.
- ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.
Cited by
- Differential regulation of protease activated receptor-1 and tissue plasminogen activator expression by shear stress in vascular smooth muscle cells.
- A lymph node metastatic mouse model reveals alterations of metastasis‐related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell line
- Role of Ca2+ signaling in the regulation of endothelial permeability.
- Modulation des propriétés mécaniques de cellules stimulées par l'angiotensine II, la thrombine et la bradykinine : implications vasculaires
- Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists
- Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.
- Elevated Plasma Levels of Crosslinked Fibrinogen Gamma-chain Dimer Indicate Cancer-related Fibrin Deposition and Fibrinolysis
- T-Cell receptor signaling pathway exerts a negative control on thrombin-mediated increase in [Ca2+]i and p38 MAPK activation in Jurkat T cells: implication of the tyrosine kinase p56Lck.
- Application of bioencapsulated proteinases and peptides for wound gealing
- NEUTROPHIL PRODUCTS CONTROL THE EXPRESSION OF PROGESTERONE RECEPTORS AND MATRIX METALLOPROTEINASE-1 IN THE DECIDUAL AND MYOMETRIUM AND ARE POSSIBLE REGULATORS OF PREMATURE LABOR
- Novel vitamin K-dependent pathways regulating cell survival
- Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells.
- Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury.
- Arachidonic acid and docosahexaenoic acid suppress thrombin‐evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation
- Motor Neuron Cell Death in Wobbler Mutant Mice Follows Overexpression of the G-protein-coupled, Protease-activated Receptor for Thrombin
- Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
- Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.
- Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins.
- The Emerging Role of the Thrombin Receptor (PAR-1) in Melanoma Metastasis - a Possible Therapeutic Target
- Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia
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