Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution.
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Summary
Gene families resulting from genome duplications in humans and mice and the frequency distribution of gene family size showed that duplicated genes are almost as likely to acquire a new and essential function as to be lost through acquisition of mutations that compromise protein function.
- Type
- article
- Published
- 1997-11-01
- Cited by
- 237
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W1763075905
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12973050
Keywords
Gene duplication, Biology, Functional divergence, Gene, Genome
References
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- The Sheltering of Lethals
- The coevolution of gene family trees.
- Loss of duplicate gene expression after polyploidisation
- Polymorphism and loss of duplicate gene expression: a theoretical study with application of tetraploid fish.
- Evolution of Cellular DNA Content in Teleost Fishes
- Evolution from fish to mammals by gene duplication.
- Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse.
- Conservation, Duplication, and Divergence of Developmental Genes During Chordate Evolution
- On some principles governing molecular evolution.
- Invasion and maintenance of a gene duplication.
- Rapid loss of duplicate gene expression by natural selection
Cited by
- Genome dynamics of the major histocompatibility complex: insights from genome paralogy
- Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif
- Modeling sequence evolution.
- Molecular Evolution of MADS-box Genes in Cotton ( Gossypium L.)
- Comparative Mapping and Genome Rearrangement
- Analyzing and modeling large biological networks: inferring signal transduction pathways
- Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates
- The paleopolyploid nature of the soybean genome: duplicate gene identification, regional sequence characterization and expression studies
- Functional divergence and age distribution of vertebrate gene families
- Identification de deux gènes NPR1chez les VITACEAE, analyse de leur diversité de séquences et interactions avec les facteurs de transcription VvTGA
- Expression and function analysis of two naturally truncated MyD88 variants in the Pacific oyster Crassostrea gigas.
- Analyses théoriques de l'expansion des familles de gènes impliqués dans des maladies dominantes
- On the Source of Mutational Robustness in Genetic Networks of Yeast
- The evolution of gene duplicates.
- A yeast prion provides a mechanism for genetic variation and phenotypic diversity
- Evidence for symmetric chromosomal inversions around the replication origin in bacteria
- Evolutionary analysis of the insulin-relaxin gene family from the perspective of gene and genome duplication events.
- The zebrafish genome: a review and msx gene case study.
- Duplication and relocation of the functional DPY19L2 gene within low copy repeats
- Analytical methods for detecting paralogy in molecular datasets.
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