Molecular Alterations of TP53 are a Defining Feature of Ovarian High-Grade Serous Carcinoma: A Rereview of Cases Lacking TP53 Mutations in The Cancer Genome Atlas Ovarian Study
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Summary
It is proposed that lack of molecular alterations of TP53 are essentially inconsistent with the diagnosis of ovarian HGSC and that tumors diagnosed as such should be rigorously reassessed to achieve correct classification.
- Type
- article
- Published
- 2016-01-01
- Cited by
- 155
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W1758302002
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22671202
Keywords
Serous carcinoma, Serous fluid, Pathology, Carcinoma, Ovarian carcinoma
References
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- Integrated Genomic Characterization of Endometrial Carcinoma
- Results From Four Rounds of Ovarian Cancer Screening in a Randomized Trial
- High‐grade ovarian serous carcinoma exhibits significantly higher p16 expression than low‐grade serous carcinoma and serous borderline tumour
- Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
- p16 Expression in Primary Ovarian Mucinous and Endometrioid Tumors and Metastatic Adenocarcinomas in the Ovary: Utility for Identification of Metastatic HPV-Related Endocervical Adenocarcinomas
- Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma
- Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
- Diagnosis of Ovarian Carcinoma Cell Type is Highly Reproducible: A Transcanadian Study
- The Oviduct and Ovarian Cancer: Causality, Clinical Implications and “Targeted Prevention”
- Ovarian carcinoma histotype determination is highly reproducible, and is improved through the use of immunohistochemistry
- Distinction of Primary Ovarian Mucinous Tumors and Mucinous Tumors Metastatic to the Ovary: A Practical Approach With Guidelines for Prediction of Primary Site for Metastases of Uncertain Origin
- Immunohistochemistry for estrogen and progesterone receptors in the distinction of primary and metastatic mucinous tumors in the ovary: an analysis of 124 cases
- The Development of High-grade Serous Carcinoma From Atypical Proliferative (Borderline) Serous Tumors and Low-grade Micropapillary Serous Carcinoma: A Morphologic and Molecular Genetic Analysis
- Fallopian tube precursors of ovarian low‐ and high‐grade serous neoplasms
- Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7
- Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-grade and High-grade Carcinomas
- Low-grade serous carcinomas of the ovary contain very few point mutations
- Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis
- ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
Cited by
- The rise of genomic profiling in ovarian cancer
- Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review
- Ovarian cancer: Status of homologous recombination pathway as a predictor of drug response.
- The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
- Homologous recombination deficiency and ovarian cancer.
- TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data
- Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues
- Immunohistochemical Profiling of Endometrial Serous Carcinoma
- Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing
- Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma
- Epithelial ovarian cancer.
- Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition
- Integrated proteogenomic characterization of human high grade serous ovarian cancer
- TP53 mutations in epithelial ovarian cancer
- Pathogenesis and heterogeneity of ovarian cancer
- Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment
- Fifth Ovarian Cancer Consensus Conference: individualized therapy and patient factors.
- Recent Advances in Understanding, Diagnosing, and Treating Ovarian Cancer
- TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer
- Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician
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