Drosophila Wingless is loaded on exosome-like vesicles but forms a gradient in an exosome-independent manner
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Summary
It is found that, in medium conditioned by Wingless‐expressing Drosophila S2 cells, Wingless is present on exosome‐like vesicles and that this fraction activates signal transduction, which allows us to conclude from in vivo Rab11 knockdown experiments, that exosomes are unlikely to contribute to Wingless secretion and gradient formation in wing discs.
- Type
- article
- Published
- 2012-10-31
- Cited by
- 187
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1723090406
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23247114
Keywords
Exosome, Biology, Microvesicles, Cell biology, Secretion
References
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- Wingless promotes cell survival but constrains growth during Drosophila wing development
- Proteomic profiling of exosomes: Current perspectives
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- Sprinter: a novel transmembrane protein required for Wg secretion and signaling
- The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network.
- Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication.
Cited by
- Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.
- Extracellular vesicles shuffling intercellular messages: for good or for bad.
- Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors.
- The effects of Sulf1 on canonical and non-canonical Wnt signalling in Xenopus
- Mechanisms of Wntless trafficking and Wnt signaling
- Exosome Biogenesis, Regulation, and Function in Viral Infection
- Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion
- The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.
- Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants.
- The emerging role of exosomes in Wnt secretion and transport.
- Filopodia-based Wnt transport during vertebrate tissue patterning
- Extracellular vesicles as emerging intercellular communicasomes
- Carrier of Wingless (Cow), a Secreted Heparan Sulfate Proteoglycan, Promotes Extracellular Transport of Wingless
- Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila
- Hedgehog on the move: a precise spatial control of Hedgehog dispersion shapes the gradient.
- The Emerging Role of Exosomes in Epithelial–Mesenchymal-Transition in Cancer
- Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals
- Cancer becomes wasteful: emerging roles of exosomes† in cell-fate determination
- 14‐3‐3 and β‐catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway
- Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine.
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