Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development.
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Summary
It is demonstrated that the c-kit orthologue identified in this study is required both for normal migration and for survival of embryonic melanocytes and is not essential for hematopoiesis or primordial germ cell development.
- Type
- article
- Published
- 1999-08-01
- Cited by
- 328
- References
- 95
- OpenAlex
- https://openalex.org/W1718193936
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6680650
Keywords
Biology, Zebrafish, Danio, Morphogenesis, Gene duplication
References
- Molecular bases of dominant negative and loss of function mutations at the murine c‐kit/white spotting locus: W37, Wv, W41 and W.
- The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.
- Steel and c‐kit in the development of avian melanocytes: A study of normally pigmented birds and of the hyperpigmented mutant silky fowl
- Genetic analysis of steel and the PG-M/versican-encoding gene AxPG as candidates for the white (d) pigmentation mutant in the salamander Ambystoma mexicanum
- The Occurrence of a Dominant Spotting Mutation in the House Mouse.
- Morphogenesis of the neural crest.
- Optimized conditions for cloning PCR products into an XcmI T-vector.
- Spatial visualization of apoptosis using a whole-mount in situ DNA end-labeling technique.
- The c-kit receptor ligand functions as a mast cell chemoattractant.
- Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos.
- c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities.
- In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment.
- Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts.
- The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.
- Hereditary anemias of the mouse: a review for geneticists.
- Sequential segregation and fate of developmentally restricted intermediate cell populations in the neural crest lineage.
- Primary structure of c‐kit: relationship with the CSF‐1/PDGF receptor kinase family–oncogenic activation of v‐kit involves deletion of extracellular domain and C terminus.
- Neural crest diversification.
- Stem cell factor and hematopoiesis.
- Quantitative analysis of the normal and four alternative degrees of an inherited macrocytic anemia in the house mouse. I. Number and size of erythrocytes.
Cited by
- Development of Diverse Tools for Pigment Cell Research and Drug Screening in Zebrafish
- The genetic basis of pigment pattern differentiation in Lake Malawi African cichlids
- The genetic regulation of pigment cell development.
- Regulation of Progenitor Cell Proliferation During Zebrafish Fin Regeneration
- Roles for activator protein 2 (AP-2) transcription factors in zebrafish neural crest development
- Clonal and Lineage Analysis of Melanocyte Stem Cells and Their Progeny in the Zebrafish
- Genetic regulation of neural crest cell differentiation
- Developmental biology of zebrafish myeloid cells.
- Analysis of Sox10 target genes in zebrafish early development
- Exploring erythropoiesis of common carp (Cyprinus carpio) using an in vitro colony assay in the presence of recombinant carp kit ligand A and erythropoietin.
- A Fundamental Investigation into the Presence of Interstitial Cells of Cajal within the Gastrointestinal Tract of Dania rerio
- Molecular and developmental contributions to divergent pigment patterns in marine and freshwater sticklebacks
- Small molecule screening identifies targetable zebrafish pigmentation pathways
- The zebrafish as a model system for human disease.
- The Transient Receptor Potential Melastatin 7 is required for early melanophore survival and facets of both embryonic and larval motility in zebrafish
- Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
- Genetic analysis of the hooded phenotype in the rat
- Genetic characterization and in vivo image analysis of novel zebrafish Danio rerio pigment mutants.
- Cold exposure down‐regulates zebrafish pigmentation
- The Establishment and Regulation of Melanocyte Stem Cells in Zebrafish
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