Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA.
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Summary
Analysis of the sequences of these antibodies indicates that they derive from autoreactive B cells that were clonally expanded and whose V region genes have undergone numerous somatic mutations, supporting the hypothesis that the activation of these clones is Ag-driven.
- Type
- article
- Published
- 1992-03-01
- Cited by
- 178
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1715957537
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22572578
Keywords
Anti-nuclear antibody, Histone, Epitope, Antibody, Biology
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