Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.
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Summary
Compound 29 reduced apomorphine-induced climbing and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head twitching without observable catalepsy, even at the highest dose tested, and is a promising candidate as a multi-target antipsychotic treatment.
- Type
- article
- Published
- 2015-11-15
- Cited by
- 24
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1712097734
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21789165
Keywords
Chemistry, Piperazine, Benzoxazole, hERG, Piperidine
References
- Drug treatment of schizophrenia
- Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects.
- Discovery of selective dopamine D3 ligands: II. 2-[4-[3-(4-aryl-1-piperazinyl)propoxy]phenyl]benzimidazole partial agonists
- Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.
- Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
- Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
- The 5-HT7 receptor is involved in allocentric spatial memory information processing
- Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.
- A rabbit model for evaluation of chlorpromazine-induced orthostatic hypotension.
- Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents.
- Overexpression of alpha2C-adrenoceptors impairs water maze navigation.
- Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology
- Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat.
- Schizophrenia: from phenomenology to neurobiology
- Enhanced Cortical Dopamine Output and Antipsychotic-like Effects of Raclopride by α2 Adrenoceptor Blockade
- Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis
- From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.
- Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia
- H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs
- The 5-HT2C receptor and antipsychoticinduced weight gain – mechanisms and genetics
Cited by
- Polypharmacology of dopamine receptor ligands.
- Rapid Pd-Catalyzed Synthesis of Piperazine Scaffolds Under Aerobic and Solvent-Free Conditions
- Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions
- The Isoxazole Ring and Its N‐Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics
- Spectroscopic (FT-IR, FT-Raman, UV, NMR, NLO) investigation, molecular docking and molecular simulation dynamics on 1-Methyl-3-Phenylpiperazine
- Elemental Sulfur-Promoted Oxidative Rearranging Coupling between o-Aminophenols and Ketones: A Synthesis of 2-Alkyl benzoxazoles under Mild Conditions.
- Recent advance in oxazole-based medicinal chemistry.
- Current Concepts and Treatments of Schizophrenia
- Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
- Multi-Target Approach for Drug Discovery against Schizophrenia
- Synthesis, crystal structure, DFT calculations, Hirshfeld surface, vibrational and optical properties of a novel hybrid non-centrosymmetric material (C10H15N2)2H2P2O7
- Multi-targeted drug design strategies for the treatment of schizophrenia
- Biological activity of 3-(2-benzoxazol-5-yl)alanine derivatives
- Piperidine nucleus in the field of drug discovery
- Robust and predictive QSAR models for predicting the D2, 5-HT1A, and 5-HT2A inhibition activities of fused tricyclic heterocycle piperazine (piperidine) derivatives as atypical antipsychotic drugs
- Computational approaches for the design of novel dopamine D2 and serotonin 5-HT2A receptor dual antagonist towards schizophrenia
- INVESTIGATION OF THE FORMATION REACTION OF σ-ADDUTS OF 2-R-5,7-DINITROBENZOXAZOLES
- An overview of Schizophrenia treatment options
- Crystal structure analysis, magnetic measurement, DFT studies, and adsorption properties of novel 1-(2,5-dimethyphenyl)piperazine tetrachlorocobaltate hydrate
- Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution
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