Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein
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Summary
A dose-dependent regulation of the HPV18 E6/E7 promoter by E2 is suggested due to variable occupancy of its binding sites, which have antagonizing effects on the activity of the E5/E6 promoter.
- Type
- article
- Published
- 1997-01-01
- Cited by
- 218
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W1672426070
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20624125
Keywords
Biology, TATA box, Bovine papillomavirus, Molecular biology, Promoter
References
- Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure.
- Characterization of the human papillomavirus E2 protein: evidence of trans‐activation and trans‐repression in cervical keratinocytes.
- The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding.
- The structure, function, and regulation of papillomaviral genes in infection and cervical cancer.
- Structural and mutational analysis of E2 trans‐activating proteins of papillomaviruses reveals three distinct functional domains.
- Bovine papilloma virus encoded E2 protein activates lymphokine genes through DNA elements, distinct from the consensus motif, in the long control region of its own genome.
- Short protocols in molecular biology
- A dimer of BPV‐1 E2 containing a protease resistant core interacts with its DNA target.
- Transforming activity of bovine and human papillomaviruses in cultured cells.
- Sequence‐specific and general transcriptional activation by the bovine papillomavirus‐1 E2 trans‐activator require an N‐terminal amphipathic helix‐containing E2 domain.
- Interactions between papillomavirus proteins and tumor suppressor gene products.
- The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2‐dependent enhancer.
- Low-affinity E2-binding site mediates downmodulation of E2 transactivation of the human papillomavirus type 8 late promoter
- The papillomavirus E2 regulatory proteins.
- Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters
- Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements
- Papillomavirus DNA replication
- The bovine papillomavirus type 1 (BPV1) replication protein E1 modulates transcriptional activation by interacting with BPV1 E2
- E2 represses the late gene promoter of human papillomavirus type 8 at high concentrations by interfering with cellular factors
- Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.
Cited by
- The E8∧E2 Gene Product of Human Papillomavirus Type 16 Represses Early Transcription and Replication but Is Dispensable for Viral Plasmid Persistence in Keratinocytes
- Novel Approaches for Vaccination Against HPV-Induced Cancers.
- An investigation of the contribution of cigarette smoking and human papillomavirus infection to the epigenetic modulation of cellular genes in cervical epithelium
- The Role of Polyadenylation in Human Papillomavirus Type 16 Late Gene Expression
- Multiple Roles of Brd4 in the Human Papillomavirus Life Cycle
- The role of the PSD95/Dlg/ZO-1 (PDZ) binding motif of human papillomavirus type 18 E6 oncoprotein in the virus life cycle
- An investigation of post-translational modification of human papillomavirus E4 and the role of modified E4 proteins during the virus life cycle
- REGULATION OF SERINE-ARGININE PROTEIN KINASE 1 FUNCTIONS BY HUMAN PAPILLOMAVIRUS
- PRIMERJAVA ROČNE IN AVTOMATSKE IZOLACIJE DNA V POSTOPKU DOKAZOVANJA OKUB S HUMANIMI VIRUSI PAPILOMA
- Interactions of the human papillomavirus E6 protein and their role in the persistence of viral episomes
- Understanding the evolutionary history of the papillomaviruses
- Analysis of Pathways Affected by the Viral Oncogenes in Human Papillomavirus 16-Induced Neoplastic Progression
- Cutaneous Human Papillomaviruses
- Human papillomavirus-associated cancers.
- Investigating the role of human papillomavirus DNA replication in the development of cervical cancer
- Methylation status of HPV16 E2‐binding sites classifies subtypes of HPV‐associated oropharyngeal cancers
- Methylation of human papillomavirus DNA : biological significance and clinical utility
- HPV protein/peptide vaccines: from animal models to clinical trials.
- Human papillomaviruses and cervical cancer.
- Estudo in vitro sobre a interação celular e vias endocíticas de papilomavírus humano (HPV) em leucócitos do sangue periférico.
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