Invadopodia: unique methods for measurement of extracellular matrix degradation in vitro.
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Summary
There are two aspects to the assay: first, the visual, qualitative determination of the ability of a cell line to make invadopodia and, second, the quantitative measurement of this activity.
- Type
- article
- Published
- 2001-01-01
- Cited by
- 135
- References
- 26
- OpenAlex
- https://openalex.org/W1654219198
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34966320
Keywords
Invadopodia, Extracellular matrix, Matrix (chemical analysis), Cell biology, Biology
References
- Proteases associated with invadopodia, and their role in degradation of extracellular matrix.
- Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion.
- A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.
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- The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactions.
- Cellular invasion into matrix beads: localization of beta 1 integrins and fibronectin to the invadopodia.
- Integrin alpha 3 beta 1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells.
- An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation
- Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells
- Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins
- Serum Requirement for in vitro Invasion by Tumor Cells
- Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites
- A collagenase assay using [3H-methyl]collagen.
- Phagocytic capacity of invasive malignant cells in three-dimensional culture
- Activation of β1 Integrin Signaling Stimulates Tyrosine Phosphorylation of p190 RhoGAP and Membrane-protrusive Activities at Invadopodia*
- Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
- Characterization of very acidic phagosomes in breast cancer cells and their association with invasion.
- Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.
- Comparison of tumor cell invasion assays: human amnion versus reconstituted basement membrane barriers.
- Diversity of melanoma plasma membrane proteinases: inhibition of collagenolytic and cytolytic activities by minocycline.
Cited by
- p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2
- Signaling inputs to invadopodia and podosomes
- Roles of WIP and WICH/WIRE proteins in formation and maturation of invasive protrusions in human breast cancer cells
- Breast cancer cell movement: imaging invadopodia by TIRF and IRM microscopy.
- Identification of a Novel Formin-GAP Complex and Its Role in Macrophage Migration and Phagocytosis
- MLCK/actin Interaction in the Contracting A7r5 Cell and Vascular Smooth Muscle
- Invadopodia formation in breast cancer
- Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function
- CIP4 and Src in Promoting the Migration and Invasion of Breast Cancers
- Integrin Trafficking and the Control of Cell Migration
- Investigating the role of ADP-ribosylation factor 6 in tumor cell invasion and extracellular signal-regulated kinase activation.
- EGF enhances low-invasive cancer cell invasion by promoting IMP-3 expression
- Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion
- Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
- A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation
- Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis
- The role of dynamin in the assembly and function of podosomes and invadopodia.
- Transcriptional regulation of metastatic progression in lung adenocarcinoma
- Invadopodia: Specialized Cell Structures for Cancer Invasion
- WIP is necessary for matrix invasion by breast cancer cells.
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