Subunit‐specific mechanisms and proton sensitivity of NMDA receptor channel block
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Summary
Data suggest a tight coupling between the proton sensor and the ion channel gate as well as unique subunit‐specific mechanisms of channel block, which may be possible to design sub unit‐selective channel blockers.
- Type
- article
- Published
- 2007-05-01
- Cited by
- 186
- References
- 105
- Access
- Open access
- OpenAlex
- https://openalex.org/W1606744897
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8379461
Keywords
Chemistry, NMDA receptor, Biophysics, Dizocilpine, Protein subunit
References
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- Transport of amantadine and rimantadine through the blood-brain barrier.
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- Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels.
- Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor.
Cited by
- Structure, function, and pharmacology of NMDA receptor channels.
- Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors
- Handbook of ion channels
- Behavioral analysis of NR2C knockout mouse reveals deficit in working memory and acquisition of conditioned fear
- The Functional Expression of N-Methyl-D-Aspartate Glutamate-Type Receptors by Megakaryocytes and Platelets
- Studies of GluN2C-containing NMDA receptors in schizophrenia-like behaviors and fear learning; Relevance to the glutamate hypofunction hypothesis of schizophrenia
- Dissociable antidepressant-like and abuse-related effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 in rats.
- Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus.
- Mechanism of block and behavioral effects of the N-methyl-D-aspartate receptor antagonists memantine and ketamine
- Mechanistic basis of NMDA receptor channel property variation
- Activation of recombinant NR1/NR2C NMDA receptors
- A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons
- Modulation of NMDA Receptor Activity During Physiological and Pathophysiological Events
- The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation
- Some non-conventional biomolecular targets for diamidines. A short survey.
- Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice.
- Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor.
- Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors
- Binding of ArgTX-636 in the NMDA Receptor Ion Channel
- Brain tumors and epilepsy: pathophysiology of peritumoral changes
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