The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins
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Summary
It is proposed that the IRSome is an important target for treatment of various age-related diseases including cancer, after it was discovered that IRSs form high-molecular-mass complexes even without IGF/insulin stimulation, which contain proteins which modulate tyrosine phosphorylation of IRSs by receptor kinases, control IRS stability, and determine intracellular localization of IRSS.
- Type
- review
- Published
- 2015-05-26
- Cited by
- 40
- References
- 229
- Access
- Open access
- OpenAlex
- https://openalex.org/W1602996820
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:788989
Keywords
Insulin receptor, Insulin, GRB10, IRS2, Receptor tyrosine kinase
References
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Cited by
- IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation
- A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes
- IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation
- Energy status and ovarian follicular development
- USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.
- A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes
- 40 YEARS OF IGF1: IGF1 receptor signaling pathways
- IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
- Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly
- Ocimum basilicum miRNOME revisited: A cross kingdom approach.
- Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates
- Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1–mediated p53/KLF4 complex stabilization
- Etiology of Metabolic Syndrome and Dietary Intervention
- IGF research 2016-2018.
- Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration
- [Long-term high-fat diet inhibits hippocampal expression of insulin receptor substrates and accelerates cognitive deterioration in obese rats].
- Oxygen and embryonic growth: the role of insulin-like growth factor signaling.
- Integrative Analysis of the Genes Induced by the Intestine Microbiota of Infant Born to Term and Breastfed
- Effects of COVID-19, diabetes mellitus, and cardiovascular diseases on insulin receptor substrate-1 amount in the blood plasma of patients
- IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1
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